Publication Name	World Journal of Clinical Oncology
Manuscript ID	61570
Country	United States

Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Racial disparities in immune-related adverse events of immune checkpoint inhibitors and association with survival based on clinical and biochemical responses
Manuscript Source	Unsolicited Manuscript
All Author List	Monica Peravali, Cristiane Gomes-Lima, Eshetu Tefera, Mairead Baker, Mamta Sherchan, Saira Farid, Kenneth Burman, Florina Constantinescu and Irina Veytsman
Funding Agency and Grant Number
Corresponding Author	Monica Peravali, MD, Academic Fellow, Department of Hematology/Oncology, MedStar Washington Hospital Center, 110 Irving Street, Washington, DC 20010, United States. monica.peravali@medstar.net
Key Words	Immunotherapy; Adverse events; Endocrine; Survival; Race; Minority
Core Tip	Immune checkpoint inhibitors have revolutionized the treatment of many types of cancer, yet they cause various immune-related adverse events (irAEs), notably thyroid dysfunction. Development of irAEs has been reported as a surrogate marker of improved survival. However, minority racial group representation is a limitation in immunotherapy trials. In this retrospective study, we evaluate the association of development of irAEs to survival outcomes in patients treated with immune checkpoint inhibitors for advanced stage solid malignancies. The racial diversity of the population of patients is a unique feature of this study. Our data concluded a positive correlation of irAEs development with increased probability of survival and demonstrates a positive correlation with Caucasian race and overall survival.
Citation	Peravali M, Gomes-Lima C, Tefera E, Baker M, Sherchan M, Farid S, Burman K, Constantinescu F, Veytsman I. Racial disparities in immune-related adverse events of immune checkpoint inhibitors and association with survival based on clinical and biochemical responses. World J Clin Oncol 2021; 12(2): 103-114

Received	2020-12-14 15:39
Peer-Review Started	2020-12-14 15:41
To Make the First Decision
Return for Revision	2020-12-24 19:05
Revised	2021-01-04 19:15
Second Decision	2021-01-12 06:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-01-21 22:16
Articles in Press	2021-01-21 22:16
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-02-01 05:38

ISSN	2218-4333 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com