Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	62058
Country	Ireland

Category	Immunology
Manuscript Type	Review
Article Title	Hypoxia and its impact on the tumour microenvironment of gastroesophageal cancers
Manuscript Source	Invited Manuscript
All Author List	Ross King, Conall Hayes, Claire L Donohoe, Margaret R Dunne, Maria Davern and Noel E Donlon
Funding Agency and Grant Number
Corresponding Author	Noel E Donlon, BM BCh, Surgical Oncologist, Department of Surgery, St. James’s Hospital Campus, Trinity Translational Medicine Institute, James Street, Dublin D8, Ireland. donlonn@tcd.ie
Key Words	Esophageal cancer; Gastric cancer; Tumor hypoxia; Tumour microenvironment; Gastroesophageal cancer
Core Tip	Improved methods in measuring the oxygen status in the tumour microenvironment have allowed for a better understanding of the role of hypoxia and how it contributes to tumour progression and treatment resistance. These methods include non-invasive imaging techniques as well as validated hypoxic molecular signatures. Specific hypoxia-targeted therapies have not lived up to their expectations but may have potential application in combination with traditional treatment approaches in gastroesophageal cancer.
Citation	King R, Hayes C, Donohoe CL, Dunne MR, Davern M, Donlon NE. Hypoxia and its impact on the tumour microenvironment of gastroesophageal cancers. World J Gastrointest Oncol 2021; 13(5): 312-331

Received	2020-12-27 16:40
Peer-Review Started	2020-12-27 17:00
To Make the First Decision
Return for Revision	2021-02-14 06:38
Revised	2021-02-24 22:51
Second Decision	2021-04-06 08:11
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-04-14 14:20
Articles in Press	2021-04-14 14:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-04-25 04:00

ISSN	1948-5204 (online)
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