Publication Name	World Journal of Clinical Cases
Manuscript ID	62249
Country	China

Category	Genetics & Heredity
Manuscript Type	Case Report
Article Title	New mechanism of partial duplication and deletion of chromosome 8: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Yan Jiang, Shuang Tang, Fang He, Jue-Xin Yuan and Zhu Zhang
Funding Agency and Grant Number
Corresponding Author	Shuang Tang, MBBS, Attending Doctor, Office of Prenatal Diagnosis, Mianyang People's Hospital, No. 10-12 West Jiannan Road, Fuchen District, Mianyang 621000, Sichuan Province, China. 154179285@qq.com
Key Words	Chromosome 8; Spontaneous mutation; Mitosis; Non-invasive prenatal testing; Case report
Core Tip	The mechanism of partial deletion/duplication at the end of chromosome 8 involves two prevailing theories: Parental chromosome 8 inversion producing unbalanced gametes, and recombination hot spot of chromosome 8p. Although the recombination hot spot of chromosome 8q occurring during mitosis is rarely reported, it was confirmed in the present case. Non-invasive prenatal testing (NIPT) for copy number variation has been used, but 40% or less mosaic abnormalities cannot be detected by NIPT. When chromosome 8 partial deletion/duplication occurs, in addition to the unbalanced gamete production caused by parental chromosome 8 inversion, attention should be paid to the mechanism of spontaneous recombination in meiosis or mitosis.
Citation	Jiang Y, Tang S, He F, Yuan JX, Zhang Z. New mechanism of partial duplication and deletion of chromosome 8: A case report. World J Clin Cases 2021; 9(24): 7139-7145

Received	2021-02-21 11:28
Peer-Review Started	2021-02-21 11:28
To Make the First Decision
Return for Revision	2021-05-06 18:36
Revised	2021-05-23 09:45
Second Decision	2021-06-07 12:57
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-06-07 13:15
Articles in Press	2021-06-07 13:15
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-07-16 07:25
Typeset the Manuscript	2021-08-16 15:49

ISSN	2307-8960 (online)
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