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6/4/2021 10:08:13 AM | Browse: 85 | Download: 44
Publication Name World Journal of Gastroenterology
Manuscript ID 62457
Country/Territory Germany
Category Surgery
Manuscript Type Retrospective Study
Article Title Stem cell injection for complex anal fistula in Crohn’s disease: A single-center experience
Manuscript Source Invited Manuscript
All Author List Oliver Schwandner
Funding Agency and Grant Number
Corresponding Author Oliver Schwandner, FASCRS, MD, Professor, Department of Proctology, Krankenhaus Barmherzige Brueder, Pruefeninger Str 86, Regensburg 93049, Germany. oliver.schwandner@barmherzige-regensburg.de
Key Words Complex anal fistula; Crohn’s disease; Stem cell therapy; Mesenchymal stem cells; Darvadstrocel; Treatment; Surgery; Outcomes
Core Tip This is a retrospective single-center study on the application of allogenic, adipose-derived mesenchymal stem cells (darvadstrocel) for complex perianal fistula associated with Crohn’s disease, providing structured inclusion and exclusion criteria for 12 patients. The current data demonstrate that the management by local stem cell therapy is safe and effective. However, based on the small patient sample size and the retrospective analysis of routine clinical data, a general conclusion remains limited. Therefore, further prospective controlled studies are mandatory to assess the definite role of adipose-derived mesenchymal stem cells for complex anal fistula in Crohn’s disease.
Citation Schwandner O. Stem cell injection for complex anal fistula in Crohn’s disease: A single-center experience. World J Gastroenterol 2021; In press
Received
2021-01-09 10:51
Peer-Review Started
2021-01-09 10:52
To Make the First Decision
Return for Revision
2021-01-23 03:45
Revised
2021-03-10 14:55
Second Decision
2021-06-04 08:50
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-06-04 10:08
Articles in Press
2021-06-04 10:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Jia-Ru Fan
Reviewer Code 00049331, 00036458, and 03812467
Editorial Director
Journal Chief Editor
Company Chief Editor Jia-Ping Yan
Language Editor
Production Editor
Responsible Production Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 62457_Auto_Edited-JPY.docx
Answering Reviewers 62457-Answering reviewers.pdf
Audio Core Tip 62457-Audio core tip.m4a
Biostatistics Review Certificate 62457-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 62457-Conflict-of-interest statement.pdf
Copyright License Agreement 62457-Copyright license agreement.pdf
Institutional Review Board Approval Form or Document 62457-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 62457-Language certificate.pdf
Peer-review Report 62457-Peer-review(s).pdf
Scientific Misconduct Check 62457-Bing-Wang JL-1.jpg
Scientific Misconduct Check 62457-Bing-Fan JR-2.png
Scientific Misconduct Check 62457-Scientific misconduct check.pdf
Scientific Editor Work List 62457-Scientific editor work list.pdf