Publication Name	World Journal of Gastroenterology
Manuscript ID	62457
Country	Germany

Category	Surgery
Manuscript Type	Retrospective Study
Article Title	Stem cell injection for complex anal fistula in Crohn’s disease: A single-center experience
Manuscript Source	Invited Manuscript
All Author List	Oliver Schwandner
Funding Agency and Grant Number
Corresponding Author	Oliver Schwandner, FASCRS, MD, Professor, Department of Proctology, Krankenhaus Barmherzige Brueder, Pruefeninger Str 86, Regensburg 93049, Germany. oliver.schwandner@barmherzige-regensburg.de
Key Words	Complex anal fistula; Crohn’s disease; Stem cell therapy; Mesenchymal stem cells; Darvadstrocel; Treatment; Surgery; Outcomes
Core Tip	This is a retrospective single-center study on the application of allogenic, adipose-derived mesenchymal stem cells (darvadstrocel) for complex perianal fistula associated with Crohn’s disease, providing structured inclusion and exclusion criteria for 12 patients. The current data demonstrate that the management by local stem cell therapy is safe and effective. However, based on the small patient sample size and the retrospective analysis of routine clinical data, a general conclusion remains limited. Therefore, further prospective controlled studies are mandatory to assess the definite role of adipose-derived mesenchymal stem cells for complex anal fistula in Crohn’s disease.
Citation	Schwandner O. Stem cell injection for complex anal fistula in Crohn’s disease: A single-center experience. World J Gastroenterol 2021; 27(24): 3643-3653

Received	2021-01-09 10:51
Peer-Review Started	2021-01-09 10:52
To Make the First Decision
Return for Revision	2021-01-23 03:45
Revised	2021-03-10 14:55
Second Decision	2021-06-04 08:50
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-06-04 10:08
Articles in Press	2021-06-04 10:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-06-18 03:27

ISSN	1007-9327 (print) and 2219-2840 (online)
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