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Publication Name World Journal of Clinical Cases
Manuscript ID 62491
Country/Territory China
Category Gastroenterology and Hepatology
Manuscript Type Case Report
Article Title Acute liver failure with thrombotic microangiopathy due to sodium valproate toxicity: A case report
Manuscript Source Unsolicited Manuscript
All Author List Xuan Mei, Hai-Cong Wu, Mei Ruan and Li-Rong Cai
Funding Agency and Grant Number
Corresponding Author Hai-Cong Wu, MS, Attending Doctor, Department of Hepatobiliary Internal Medicine, The 900th Hospital of PLA Joint Logistics Support Force, No.156 North of West-second Ring Road, Gulou District, Fuzhou 350025, Fujian Province, China. 847614051@qq.com
Key Words Sodium valproate; Drug-induced liver injury; Thrombotic microangiopathy; Plasma exchange; Organ transplantation; Case report
Core Tip Sodium valproate is widely used in the treatment of epilepsy in clinical practice although it has potential hepatotoxicity. Herein, we report a case of fatal acute liver failure (ALF) with thrombotic microangiopathy (TMA) caused by sodium valproate treatment. A history of chronic hepatitis B virus or combination therapy with sodium valproate and carbapenem may increase the risk of ALF. The combination therapy of plasma exchange, glucocorticoid, and supportive therapy is essential for TMA. Organ transplantation at the early stage of the disease may be the first choice for critically ill patients. Our case report can facilitate further studies on the diagnosis and therapy for ALF with TMA.
Citation Mei X, Wu HC, Ruan M, Cai LR. Acute liver failure with thrombotic microangiopathy due to sodium valproate toxicity: A case report. World J Clin Cases 2021; In press
Received
2021-01-10 14:10
Peer-Review Started
2021-01-10 14:10
To Make the First Decision
Return for Revision
2021-02-11 18:20
Revised
2021-02-21 17:03
Second Decision
2021-04-02 06:33
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-04-02 19:51
Articles in Press
2021-04-02 19:51
Publication Fee Transferred
Edit the Manuscript by Language Editor
2021-04-13 02:50
Typeset the Manuscript
ISSN 2307-8960 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Man Liu
Reviewer Code 05040484, 05326882, 02549939, 03290510, 01467363, 05040484, and 02549939
Editorial Director
Journal Chief Editor
Company Chief Editor Li Ma
Language Editor Tian-Qi Wang
Production Editor
Responsible Production Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 62491_Auto_Edited_LM_WangTQ.docx
Answering Reviewers 62491-Answering reviewers.pdf
Audio Core Tip 62491-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 62491-Conflict-of-interest statement.pdf
Copyright License Agreement 62491-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s) 62491-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate 62491-Language certificate.pdf
Peer-review Report 62491-Peer-review(s).pdf
Peer-review Report 62491-Scientific misconduct check.pdf
Scientific Misconduct Check 62491-Bing-Liu M-2.png
Scientific Editor Work List 62491-Scientific editor work list.pdf