Publication Name	World Journal of Clinical Cases
Manuscript ID	62491
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Acute liver failure with thrombotic microangiopathy due to sodium valproate toxicity: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Xuan Mei, Hai-Cong Wu, Mei Ruan and Li-Rong Cai
Funding Agency and Grant Number
Corresponding Author	Hai-Cong Wu, MS, Attending Doctor, Department of Hepatobiliary Internal Medicine, The 900th Hospital of PLA Joint Logistics Support Force, No.156 North of West-second Ring Road, Gulou District, Fuzhou 350025, Fujian Province, China. 847614051@qq.com
Key Words	Sodium valproate; Drug-induced liver injury; Thrombotic microangiopathy; Plasma exchange; Organ transplantation; Case report
Core Tip	Sodium valproate is widely used in the treatment of epilepsy in clinical practice although it has potential hepatotoxicity. Herein, we report a case of fatal acute liver failure (ALF) with thrombotic microangiopathy (TMA) caused by sodium valproate treatment. A history of chronic hepatitis B virus or combination therapy with sodium valproate and carbapenem may increase the risk of ALF. The combination therapy of plasma exchange, glucocorticoid, and supportive therapy is essential for TMA. Organ transplantation at the early stage of the disease may be the first choice for critically ill patients. Our case report can facilitate further studies on the diagnosis and therapy for ALF with TMA.
Citation	Mei X, Wu HC, Ruan M, Cai LR. Acute liver failure with thrombotic microangiopathy due to sodium valproate toxicity: A case report. World J Clin Cases 2021; 9(17): 4310-4317

Received	2021-01-10 14:10
Peer-Review Started	2021-01-10 14:10
To Make the First Decision
Return for Revision	2021-02-11 18:20
Revised	2021-02-21 17:03
Second Decision	2021-04-02 06:33
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-04-02 19:51
Articles in Press	2021-04-02 19:51
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-04-13 02:50
Typeset the Manuscript	2021-05-19 03:28

ISSN	2307-8960 (online)
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