Publication Name	World Journal of Clinical Cases
Manuscript ID	62521
Country	China

Category	Immunology
Manuscript Type	Case Report
Article Title	Pyogenic arthritis, pyoderma gangrenosum, and acne syndrome in a Chinese family: A case report and review of literature
Manuscript Source	Unsolicited Manuscript
All Author List	Ling-Yun Lu, Xue-Yang Tang, Guo-Jing Luo, Meng-Jia Tang, Yi Liu and Xi-Jie Yu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81770875 Post-Doctor Research Project, West China Hospital, Sichuan University 19HXBH053 Health and Family Planning Commission of Sichuan Province 19PJ096 1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University 2020HXFH008 1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University ZYJC18003
Corresponding Author	Xi-Jie Yu, MD, PhD, Professor, Department of Endocrinology, Laboratory of Endocrinology and Metabolism, West China Hospital, Sichuan University, No. 37 Guoxue Xiang, Chengdu 610041, Sichuan, China. xijieyu@hotmail.com
Key Words	Pyogenic arthritis, pyoderma gangrenosum, and acne syndrome; PSTPIP1; Autoinflammatory disease; Rare disease; Case report
Core Tip	Pyogenic arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome (OMIM 604416) is a rare autosomal dominant genetic disease characterized by severe autoimmune inflammation. Herein, we reported a case of a Chinese boy diagnosed with PAPA syndrome due to an E250Q mutation in the PSTPIP1 gene, and summarized the clinical characteristics, potential mechanisms and relatively effective treatments from previous literature in order to provide some useful information for a comprehensive understanding of this rare disease.
Citation	Lu LY, Tang XY, Luo GJ, Tang MJ, Liu Y, Yu XJ. Pyogenic arthritis, pyoderma gangrenosum, and acne syndrome in a Chinese family: A case report and review of literature. World J Clin Cases 2021; 9(22): 6393-6402

Received	2021-01-20 07:05
Peer-Review Started	2021-01-20 07:05
To Make the First Decision
Return for Revision	2021-03-25 06:06
Revised	2021-04-07 02:40
Second Decision	2021-05-08 06:00
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-05-08 08:38
Articles in Press	2021-05-08 08:38
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-06-24 05:20
Typeset the Manuscript	2021-07-22 01:46

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com