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4/5/2021 4:40:01 PM | Browse: 40 | Download: 63
Publication Name World Journal of Clinical Oncology
Manuscript ID 62536
Country/Territory Australia
Category Oncology
Manuscript Type Basic Study
Article Title Cytotoxic CD8+ T cells and tissue resident memory cells in colorectal cancer based on microsatellite instability and BRAF status
Manuscript Source Invited Manuscript
All Author List James Wei Tatt Toh, Angela L Ferguson, Kevin J Spring, Hema Mahajan and Umaimainthan Palendira
Funding Agency and Grant Number
Corresponding Author James Wei Tatt Toh, BSc, MBBS, Senior Lecturer, Surgeon, Division of Surgery and Anaesthesia, Department of Colorectal Surgery, Westmead Hospital, Cnr Hawkesbury and Darcy Rd, Westmead 2145, NSW, Australia. james.toh@sydney.edu.au
Key Words Tissue resident memory cells; Resident memory T cells; Colorectal cancer; Microsatellite instability; BRAF; DNA mismatch repair; Immunotherapy; Prognosis
Core Tip Prior to this study, whether T resident memory (TRM) cells exist in colorectal cancer (CRC) was poorly understood. This study has identified and characterize TRM cells within human CRC. CD8+ TRM cells are found in greater abundance in both high microsatellite instability (MSI-H) BRAF mutant and MSI-H BRAF wild type CRC when compared with their microsatellite stable counterpart. CD8+ TRM may play a role in the immunogenicity in both BRAF mutant and BRAF wild type MSI-H CRC. Further studies should focus on the potential immunogenic qualities of TRM cells and investigate potential immunotherapeutic approaches to improve treatment and survival associated with CRC based on TRM.
Citation Toh JWT, Ferguson A, Spring KJ, Mahajan H, Palendira U. Cytotoxic CD8+ T cells and tissue resident memory cells in colorectal cancer based on microsatellite instability and BRAF status. World J Clin Oncol 2021; In press
Received
2021-01-14 00:19
Peer-Review Started
2021-01-14 00:20
To Make the First Decision
Return for Revision
2021-02-15 02:55
Revised
2021-03-14 06:49
Second Decision
2021-04-02 12:13
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-04-05 16:40
Articles in Press
2021-04-05 16:40
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2021-04-15 01:41
ISSN 2218-4333 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Chen-Chen Gao
Reviewer Code 05225448
Editorial Director
Journal Chief Editor
Company Chief Editor Li Ma
Language Editor
Production Editor Li-Li Wang
Responsible Production Editor Li-Li Wang
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Full Article (Word) WJCO-12-238.docx
Manuscript File 62536_Auto_Edited_LM.docx
Answering Reviewers 62536-Answering reviewers.pdf
Audio Core Tip 62536-Audio core tip.mp3
Biostatistics Review Certificate 62536-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 62536-Conflict-of-interest statement.pdf
Copyright License Agreement 62536-Copyright license agreement.pdf
Institutional Review Board Approval Form or Document 62536-Institutional review board statement.pdf
Peer-review Report 62536-Peer-review(s).pdf
Scientific Misconduct Check 62536-Bing-Wang JL-1.jpg
Scientific Misconduct Check 62536-Scientific misconduct check.pdf
Scientific Editor Work List 62536-Scientific editor work list.pdf