BPG is committed to discovery and dissemination of knowledge
Articles in Press
2/19/2021 3:49:30 AM | Browse: 68 | Download: 15
Publication Name World Journal of Diabetes
Manuscript ID 62713
Country/Territory France
Category Developmental Biology
Manuscript Type Review
Article Title Maternal obesity as a risk factor for developing diabetes in offspring: An epigenetic point of view
Manuscript Source Invited Manuscript
All Author List Simon Lecoutre, Salwan Maqdasy and Christophe Breton
Funding Agency and Grant Number
Corresponding Author Christophe Breton, PhD, Full Professor, U1283-UMR8199-EGID, University of Lille, Institut National de la Santé Et de la Recherche Médicale, Centre National de la Recherche Scientifique, CHU Lille, Institut Pasteur de Lille, Lille 59000, France. christophe.breton@univ-lille1.fr
Key Words Development; Epigenome; Obesity; Type 2 diabetes; Adipose tissue; Beta cells
Core Tip According to the developmental origin of health and disease concept, maternal obesity and neonatal accelerated growth predispose offspring to metabolic diseases. White adipose tissue and pancreatic β-cells are key targets of developmental programming, though the underlying mechanisms remain elusive. Human and rodent studies have contributed to decipher the role of epigenetic mechanisms in the transgenerational inheritance of obesity and type 2 diabetes. In this review, we discuss the current understanding of the link between obesogenic maternal nutritional environment, developmental epigenetic adipocyte and β-cells remodeling and predisposition to obesity and type 2 diabetes later in life.
Citation Lecoutre S, Maqdasy S, Breton C. Maternal obesity as a risk factor for developing diabetes in offspring: An epigenetic point of view. World J Diabetes 2021; In press
Received
2021-01-16 12:39
Peer-Review Started
2021-01-16 12:40
To Make the First Decision
Return for Revision
2021-01-24 23:32
Revised
2021-01-30 11:26
Second Decision
2021-02-18 13:50
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-02-19 03:49
Articles in Press
2021-02-19 03:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
2021-02-26 00:49
Typeset the Manuscript
ISSN 1948-9358 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Chen-Chen Gao
Reviewer Code 03674832, and 03674832
Editorial Director
Journal Chief Editor
Company Chief Editor Li Ma
Language Editor Donna Fox
Production Editor
Responsible Production Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 62713-Review-FilipodiaCL.docx
Answering Reviewers 62713-Answering reviewers.pdf
Audio Core Tip 62713-Audio core tip.wav
Conflict-of-Interest Disclosure Form 62713-Conflict-of-interest statement.pdf
Copyright License Agreement 62713-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 62713-Language certificate.pdf
Peer-review Report 62713-Peer-review(s).pdf
Scientific Misconduct Check 62713-Bing-Wang JL-1.jpg
Scientific Misconduct Check 62713-Scientific misconduct check.pdf
Scientific Editor Work List 62713-Scientific editor work list.pdf