Publication Name	World Journal of Gastroenterology
Manuscript ID	62753
Country	Netherlands

Category	Gastroenterology & Hepatology
Manuscript Type	Evidence Review
Article Title	Pancreatitis and pancreatic cancer: A case of the chicken or the egg
Manuscript Source	Invited Manuscript
All Author List	Devica S Umans, Sanne A Hoogenboom, Noor J Sissingh, Selma J Lekkerkerker, Robert C Verdonk and Jeanin E van Hooft
Funding Agency and Grant Number
Corresponding Author	Devica S Umans, BSc, Research Associate, Department of Gastroenterology and Hepatology, Amsterdam Gastroenterology and Metabolism, Amsterdam UMC, Meibergdreef 9, Amsterdam 1105 AZ, Netherlands. d.s.umans@amsterdamumc.nl
Key Words	Pancreatic diseases; Pancreatic neoplasms; Pancreatitis; Pancreas; Chronic Pancreatitis; Exocrine pancreatic
Core Tip	It is essential to distinguish acute pancreatitis (AP) and chronic pancreatitis (CP) from pancreatic ductal adenocarcinoma (PDAC), as these diseases have different treatment options and prognoses. Idiopathic AP may be a first symptom of PDAC and endoscopic ultrasonography should therefore be considered. CP may obscure PDAC and long-standing inflammation may cause PDAC, especially in hereditary CP and patients with a history of nicotine and alcohol abuse. Patients should be counselled in cessation of tobacco and alcohol use. Pancreatitis may mimic PDAC by presenting as a mass on imaging. Specific imaging features can aid in the differentiation between benign and malignant disease.
Citation	Umans DS, Hoogenboom SA, Sissingh NJ, Lekkerkerker SJ, Verdonk RC, van Hooft JE. Pancreatitis and pancreatic cancer: A case of the chicken or the egg. World J Gastroenterol 2021; 27(23): 3148-3157

Received	2021-01-25 15:05
Peer-Review Started	2021-01-25 15:08
To Make the First Decision
Return for Revision	2021-02-27 22:48
Revised	2021-03-13 18:18
Second Decision	2021-05-08 07:24
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-05-08 08:51
Articles in Press	2021-05-08 08:51
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-05-19 20:17
Typeset the Manuscript	2021-06-04 11:41

ISSN	1007-9327 (print) and 2219-2840 (online)
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