Publication Name	World Journal of Gastroenterology
Manuscript ID	62770
Country	Italy

Category	Oncology
Manuscript Type	Evidence Review
Article Title	Pancreatic adenocarcinoma: Beyond first line, where are we?
Manuscript Source	Invited Manuscript
All Author List	Sara Cherri, Silvia Noventa and Alberto Zaniboni
Funding Agency and Grant Number
Corresponding Author	Sara Cherri, MD, Medical Assistant, Department of Oncology, Fondazione Poliambulanza, Via Bissolati 57, Brescia 25124, Italy. sara.m.cherri@gmail.com
Key Words	Pancreatic adenocarcinoma; Second-line; Chemotherapy; Targeted therapy; Immunotherapy
Core Tip	The incidence of pancreatic ductal adenocarcinoma is increasing, with anticipation of a large impact on the population. Despite achieving a survival gain in first-line treatment in the last decade, to date, little has been achieved in second-line treatment. The molecular and genetic characteristics of this tumour represent a fundamental challenge for preclinical and clinical research. In this review, we illustrate current clinical practice in second-line treatment for advanced pancreatic adenocarcinoma and the research landscape of potential future prospects.
Citation	Cherri S, Noventa S, Zaniboni A. Pancreatic adenocarcinoma: Beyond first line, where are we? World J Gastroenterol 2021; 27(17): 1847-1863

Received	2021-01-26 15:04
Peer-Review Started	2021-01-26 15:13
To Make the First Decision
Return for Revision	2021-02-27 17:34
Revised	2021-03-09 16:19
Second Decision	2021-04-09 08:48
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-04-14 05:02
Articles in Press	2021-04-14 05:02
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-04-27 01:28

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com