Publication Name	World Journal of Clinical Oncology
Manuscript ID	62807
Country	Uruguay

Category	Dentistry, Oral Surgery & Medicine
Manuscript Type	Systematic Reviews
Article Title	Mixed odontogenic tumors: A review of the clinicopathological and molecular features and changes in the WHO classification
Manuscript Source	Invited Manuscript
All Author List	Celeste Sánchez-Romero, Oslei Paes de almeida and Ronell Bologna-Molina
Funding Agency and Grant Number
Corresponding Author	Ronell Bologna-Molina, DDS, MSc, PhD, Professor, Department of Oral and Maxillofacial Pathology, Universidad de la República UDELAR (URUGUAY), NA, Montevideo 16400, Uruguay. ronellbologna@hotmail.com
Key Words	Ameloblastic fibroma; Ameloblastic fibrosarcoma; Odontogenic carcinosarcoma; Odontogenic tumors
Core Tip	We consider that the recent 2017 World Health Organization classification does not clarify the subject when considering ameloblastic fibrodentinoma (AFD) and ameloblastic fibro-odontoma (AFO) as “developing odontomas”. According to the clinical, radiographical, histopathological and molecular features of the cases reviewed, we suggest that AFD and AFO should continue to be considered benign neoplasms. Thus, the nomenclature of these mixed benign odontogenic tumors would be congruent with the classification of ameloblastic/odontogenic sarcomas. Additionally, further studies are warranted to compare these interesting odontogenic tumors and finally better clarify and understand their similarities and differences.
Citation	Sánchez-Romero C, Paes de almeida O, Bologna-Molina R. Mixed odontogenic tumors: A review of the clinicopathological and molecular features and changes in the WHO classification. World J Clin Oncol 2021; 12(12): 1227-1243

Received	2021-01-19 02:46
Peer-Review Started	2021-01-19 02:46
To Make the First Decision
Return for Revision	2021-05-14 00:36
Revised	2021-05-25 02:43
Second Decision	2021-11-24 03:38
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-11-25 02:50
Articles in Press	2021-11-25 02:50
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-12-15 16:25

ISSN	2218-4333 (online)
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