Publication Name	World Journal of Clinical Cases
Manuscript ID	62860
Country	China

Category	Oncology
Manuscript Type	Review
Article Title	Role of exosomes in the diagnosis and treatment of colorectal cancer
Manuscript Source	Invited Manuscript
All Author List	Yvette Umwali, Cong-Bo Yue, Abakundana Nsenga Ariston Gabriel, Yi Zhang and Xin Zhang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81972005 Natural Science Foundation of Shandong Province ZR2020MH238 Shandong Medical and Health Technology Development Project 2018WSB20002
Corresponding Author	Xin Zhang, FRS, MD, PhD, Academic Fellow, Associate Professor, Department of Clinical Laboratory Diagnostic, Qilu Hospital, Cheeloo College of Medicine, Shandong University, No. 107 Wenhua West Road, Jinan 250012, Shandong Province, China. xinzhang@sdu.edu.cn
Key Words	Colorectal cancer; Exosomes; Biomarker; Extracellular vesicle; Diagnosis
Core Tip	Exosomes are extracellular vesicles that mediate intercellular communication. They contain molecules such as RNAs, DNA, lipids, and proteins whose role is essential in the pathogenesis of colorectal cancer (CRC). Exosomes derived from CRC are implicated in tumorigenesis, chemotherapy resistance, and metastasis. Besides, they can enhance CRC progression by increasing tumor cell proliferation, reducing apoptosis mechanistically through upregulation or downregulation of particular essential regulatory genes, or controlling several signaling pathways. Therefore, exosomes derived from CRCs are essential biomarkers and can be used in the diagnosis.
Citation	Umwali Y, Yue CB, Gabriel ANA, Zhang Y, Zhang X. Role of exosomes in the diagnosis and treatment of colorectal cancer. World J Clin Cases 2021; 9(18): 4467-4479

Received	2021-01-22 10:44
Peer-Review Started	2021-01-22 10:47
To Make the First Decision
Return for Revision	2021-03-02 00:45
Revised	2021-03-15 13:41
Second Decision	2021-05-06 14:04
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-05-06 14:26
Articles in Press	2021-05-06 14:26
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-05-09 11:11
Typeset the Manuscript	2021-06-07 07:07

ISSN	2307-8960 (online)
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