Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	63022
Country	Indonesia

Category	Genetics & Heredity
Manuscript Type	Observational Study
Article Title	Prediction of hereditary nonpolyposis colorectal cancer using mRNA MSH2 quantitative and the correlation with nonmodifiable factor
Manuscript Source	Invited Manuscript
All Author List	Tjahjadi Robert Tedjasaputra, Mochammad Hatta, Muh Nasrum Massi, Rosdiana Natzir, Agussalim Bukhari, Rina Masadah, Muh Lutfi Parewangi, Prihantono Prihantono, Rinda Nariswati and Vincent Tedjasaputra
Funding Agency and Grant Number
Corresponding Author	Tjahjadi Robert Tedjasaputra, MD, PhD, Consultant Physician-Scientist, Doctor, Senior Lecturer, Department of Internal Medicine, Tarakan General Hospital, Medical Faculty University of Hasanuddin, Jl. Gunung Sahari XI Dalam 70B RT8 RW 3, Jakarta 10720, DKI Jakarta, Indonesia. rtedjasaputra@yahoo.com
Key Words	Colorectal cancer; MSH2 gene; Non-modifiable factors; Risk probability
Core Tip	The study has determined a definitive cut-off for grouping colorectal cancer (CRC) with its heredity using the MSH2 mRNA gene expression, which amounts to 11059 fc. The gene expressions may differ between blood and tissue sample of the CRC group, yet none between CRC and control group. Nevertheless, subsequent risk factors of family history and staging are found to be significant toward the heredity. The after-mentioned risk factors act as urgent reminder for highly risky people with family history of CRC and/or high CRC staging to have themselves and their immediate family members to undergo routine examinations as well as strict preventions.
Citation	Tedjasaputra TR, Hatta M, Massi MN, Natzir R, Bukhari A, Masadah R, Parewangi ML, Prihantono P, Nariswati R, Tedjasaputra V. Prediction of hereditary nonpolyposis colorectal cancer using mRNA MSH2 quantitative and the correlation with nonmodifiable factor. World J Gastrointest Pathophysiol 2021; 12(6): 130-142

Received	2021-01-27 01:19
Peer-Review Started	2021-01-27 01:26
To Make the First Decision
Return for Revision	2021-03-01 17:13
Revised	2021-03-13 10:34
Second Decision	2021-10-13 06:20
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-10-14 03:11
Articles in Press	2021-10-14 03:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-11-15 02:27

ISSN	2150-5330 (online)
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