Publication Name	World Journal of Gastroenterology
Manuscript ID	63093
Country	Italy

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Rethinking the Barcelona clinic liver cancer guidelines: Intermediate stage and Child-Pugh B patients are suitable for surgery?
Manuscript Source	Invited Manuscript
All Author List	Fabrizio Romano, Marco Chiarelli, Mattia Garancini, Mauro Scotti, Mauro Zago, Gerardo Cioffi, Matilde De Simone and Ugo Cioffi
Funding Agency and Grant Number
Corresponding Author	Ugo Cioffi, MD, PhD, Full Professor, Surgeon, Department of Surgery, University of Milan, Via F Sforza 35, Milano 20122, Italy. ugocioffi5@gmail.com
Key Words	Liver surgery; Hepatocellular carcinoma; Barcelona liver clinic cancer; Child B; Intermediate stage
Core Tip	According to Barcelona clinic liver cancer recommendations, intermediate stage hepatocellular carcinomas are excluded from surgery. Also Child-Pugh B patients with hepatocellular carcinomas are not usually candidate to liver resection. Nevertheless, several recent studies demonstrate that surgical resection can provide good survival benefit for patients with large and multinodular (diameter > 5 cm, number > 3) hepatocellular carcinomas or Child-Pugh B cirrhosis. In this review we discuss that liver resection may improve the short- and long-term survival of selected patients who have a stage B hepatocellular carcinoma or in the case of underlying Child-Pugh B cirrhosis.
Citation	Romano F, Chiarelli M, Garancini M, Scotti M, Zago M, Cioffi G, De Simone M, Cioffi U. Rethinking the Barcelona clinic liver cancer guidelines: Intermediate stage and Child-Pugh B patients are suitable for surgery? World J Gastroenterol 2021; 27(21): 2784-2794

Received	2021-01-24 11:23
Peer-Review Started	2021-01-24 11:27
To Make the First Decision
Return for Revision	2021-02-22 06:35
Revised	2021-02-24 20:50
Second Decision	2021-04-29 07:05
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-04-29 11:28
Articles in Press	2021-04-29 11:28
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-05-06 20:56
Typeset the Manuscript	2021-05-25 10:23

ISSN	1007-9327 (print) and 2219-2840 (online)
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