Publication Name	World Journal of Diabetes
Manuscript ID	63242
Country	India

Category	Endocrinology & Metabolism
Manuscript Type	Review
Article Title	Critical review of bone health, fracture risk and management of bone fragility in diabetes mellitus
Manuscript Source	Invited Manuscript
All Author List	Rajan Palui, Subhodip Pramanik, Sunetra Mondal and Sayantan Ray
Funding Agency and Grant Number
Corresponding Author	Sayantan Ray, MBBS, MD, Doctor, Department of Endocrinology, Medica Superspeciality Hospital and Medica Clinic, 127, EM Bypass, Mukundapur, Kolkata 700099, West Bengal, India. sayantan.ray30@gmail.com
Key Words	Diabetes; Fracture risk; Bone mineral density; Microarchitecture; Anti-diabetic drugs; Anti-osteoporosis therapy
Core Tip	Diabetes mellitus, either type 1 or type 2, has adverse effects on bone that translate into an elevated fracture risk. Different pathophysiological mechanisms contribute to poor bone health in patients with diabetes. Diagnosis of bone fragility in diabetic patients is challenging as traditional fracture predictors underestimate fracture risk in this population, contributing to the concept that diabetes affects bone quality. While waiting for further evidence, the prevention and management of bone fragility in diabetes should include identification of patients at risk, correction of modifiable risk factors, appropriate choice of anti-diabetic medications, and use of anti-osteoporosis drugs with proven efficacy.
Citation	Palui R, Pramanik S, Mondal S, Ray S. Critical review of bone health, fracture risk and management of bone fragility in diabetes mellitus. World J Diabetes 2021; 12(6): 706-729

Received	2021-01-27 13:48
Peer-Review Started	2021-01-27 13:58
To Make the First Decision
Return for Revision	2021-03-30 02:51
Revised	2021-04-08 16:21
Second Decision	2021-04-29 07:42
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-04-29 11:29
Articles in Press	2021-04-29 11:29
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-05-06 23:17
Typeset the Manuscript	2021-05-21 01:22

ISSN	1948-9358 (online)
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