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Publication Name World Journal of Gastroenterology
Manuscript ID 63304
Country/Territory China
Category Oncology
Manuscript Type Retrospective Study
Article Title Diverse expression pattern of mucin 2 in colorectal cancer indicates its mechanism related to the intestinal mucosal barrier
Manuscript Source Invited Manuscript
All Author List Guo-Lian Gan, Hua-Tao Wu, Wen-Jia Chen, Chun-Lan Li, Qian-Qian Ye, Yi-Feng Zheng and Jing Liu
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81501539
the Natural Science Foundation of Guangdong Province, China 2016A030312008
Science and Technology Planning Project of Shantou, China 200617105260368
Medical Scientific Research Foundation of Guangdong, China A2020627
“Dengfeng Project” for the construction of high-level hospital in Guangdong Province—the First Affiliated Hospital of Shantou University College Supporting Funding 202003-10
Corresponding Author Jing Liu, MD, PhD, Associate Professor, Changjiang Scholar’s Laboratory, Shantou University Medical College, No. 22 Xinling Road, Shantou 515041, Guangdong Province, China. jliu12@stu.edu.cn
Key Words Colorectal cancer; Mucin 2; Mucin; Expression; Intestinal mucosal barrier; Prognosis
Core Tip This study found that mucin 2 (MUC2) in intestinal tissues may play a protective role on the intestine and can be used as one of the indicators to evaluate the prognosis of patients with colorectal cancer (CRC). When the intestinal mucosal barrier function of patients with CRC is impaired, the serum level of MUC2 can reflect the severity of the damage. So, in CRC patients with impaired intestinal mucosal barrier function, the serum level of MUC2 could reflect the severity of the damage, providing a potential mechanism for the development of therapeutic strategies on CRC patients.
Citation Gan GL, Wu HT, Chen WJ, Li CL, Ye QQ, Zheng YF, Liu J. Diverse expression pattern of mucin 2 in colorectal cancer indicates its mechanism related to the intestinal mucosal barrier. World J Gastroenterol 2021; In press
2021-01-29 02:37
Peer-Review Started
2021-01-29 02:48
To Make the First Decision
Return for Revision
2021-02-25 04:55
2021-03-11 08:27
Second Decision
2021-06-04 09:15
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-06-04 10:04
Articles in Press
2021-06-04 10:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
2021-06-14 13:51
Typeset the Manuscript
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Jia-Ru Fan
Reviewer Code 05775440
Editorial Director
Journal Chief Editor
Company Chief Editor Jia-Ping Yan
Language Editor Tian-Qi Wang
Production Editor
Responsible Production Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 63304_Auto_Edited-JPY_WangTQ.docx
Answering Reviewers 63304-Answering reviewers.pdf
Audio Core Tip 63304-Audio core tip.m4a
Biostatistics Review Certificate 63304-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 63304-Conflict-of-interest statement.pdf
Copyright License Agreement 63304-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 63304-Grant application form(s).PDF
Signed Informed Consent Form(s) or Document(s) 63304-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 63304-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 63304-Language certificate.pdf
Peer-review Report 63304-Peer-review(s).pdf
Scientific Misconduct Check 63304-Bing-Ma YJ-1.jpg
Scientific Misconduct Check 63304-Bing-Fan JR-2.png
Scientific Misconduct Check 63304-Scientific misconduct check.pdf
Scientific Editor Work List 63304-Scientific editor work list.pdf