Publication Name	World Journal of Gastroenterology
Manuscript ID	63304
Country	China

Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Diverse expression pattern of mucin 2 in colorectal cancer indicates its mechanism related to the intestinal mucosal barrier
Manuscript Source	Invited Manuscript
All Author List	Guo-Lian Gan, Hua-Tao Wu, Wen-Jia Chen, Chun-Lan Li, Qian-Qian Ye, Yi-Feng Zheng and Jing Liu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81501539 the Natural Science Foundation of Guangdong Province, China 2016A030312008 Science and Technology Planning Project of Shantou, China 200617105260368 Medical Scientific Research Foundation of Guangdong, China A2020627 “Dengfeng Project” for the construction of high-level hospital in Guangdong Province—the First Affiliated Hospital of Shantou University College Supporting Funding 202003-10
Corresponding Author	Jing Liu, MD, PhD, Associate Professor, Changjiang Scholar’s Laboratory, Shantou University Medical College, No. 22 Xinling Road, Shantou 515041, Guangdong Province, China. jliu12@stu.edu.cn
Key Words	Colorectal cancer; Mucin 2; Mucin; Expression; Intestinal mucosal barrier; Prognosis
Core Tip	This study found that mucin 2 (MUC2) in intestinal tissues may play a protective role on the intestine and can be used as one of the indicators to evaluate the prognosis of patients with colorectal cancer (CRC). When the intestinal mucosal barrier function of patients with CRC is impaired, the serum level of MUC2 can reflect the severity of the damage. So, in CRC patients with impaired intestinal mucosal barrier function, the serum level of MUC2 could reflect the severity of the damage, providing a potential mechanism for the development of therapeutic strategies on CRC patients.
Citation	Gan GL, Wu HT, Chen WJ, Li CL, Ye QQ, Zheng YF, Liu J. Diverse expression pattern of mucin 2 in colorectal cancer indicates its mechanism related to the intestinal mucosal barrier. World J Gastroenterol 2021; 27(25): 3888-3900

Received	2021-01-29 02:37
Peer-Review Started	2021-01-29 02:48
To Make the First Decision
Return for Revision	2021-02-25 04:55
Revised	2021-03-11 08:27
Second Decision	2021-06-04 09:15
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-06-04 10:04
Articles in Press	2021-06-04 10:04
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-06-14 13:51
Typeset the Manuscript	2021-06-30 02:01

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com