Publication Name	World Journal of Gastroenterology
Manuscript ID	63338
Country	Japan

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Large-duct pattern invasive adenocarcinoma of the pancreas–a variant mimicking pancreatic cystic neoplasms: A minireview
Manuscript Source	Invited Manuscript
All Author List	Hiroki Sato, Andrew Scott Liss and Yusuke Mizukami
Funding Agency and Grant Number	Funding Agency Grant Number Japan Society for the Promotion of Science (JSPS) KAKENHI 19K17480 Japan Society for the Promotion of Science (JSPS) KAKENHI 20H03655
Corresponding Author	Hiroki Sato, MD, Academic Fellow, Doctor, Research Fellow, Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, 1-1, Midorigaoka Higashi 2-1, Asahikawa 0788510, Hokkaido, Japan. hirokisato@asahikawa-med.ac.jp
Key Words	Large-duct pattern invasive carcinoma of the pancreas; Pancreatic ductal adenocarcinoma; Pancreatic cystic disease; Clinicopathological features of pancreatic cancer; Pancreatic cancer subtype
Core Tip	This review integrates the current knowledge about large-duct pattern invasive adenocarcinoma of the pancreas [large-duct pancreatic ductal adenocarcinoma (PDA)]. This subtype is a rare exocrine pancreatic neoplasm and often mimics intraductal papillary mucinous neoplasms (IPMNs). However, its prognosis is notably different from that of IPMNs, and distinguishing this subtype from IPMNs preoperatively is crucial. We summarized the morphological features and genetic landscape of large-duct PDA, with a primary focus on its differences from other types of pancreatic cystic neoplasms. The information aid in making appropriate decisions when tackling atypical pancreatic cystic neoplasms.
Citation	Sato H, Liss AS, Mizukami Y. Large-duct pattern invasive adenocarcinoma of the pancreas–a variant mimicking pancreatic cystic neoplasms: A minireview. World J Gastroenterol 2021; 27(23): 3262-3278

Received	2021-01-28 07:19
Peer-Review Started	2021-01-28 07:21
To Make the First Decision
Return for Revision	2021-02-24 06:18
Revised	2021-03-09 14:27
Second Decision	2021-05-17 09:26
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-05-17 12:11
Articles in Press	2021-05-17 12:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-06-15 00:48

ISSN	1007-9327 (print) and 2219-2840 (online)
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