Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	63349
Country	China

Category	Oncology
Manuscript Type	Basic Study
Article Title	Combination of neutrophil gelatinase-associated lipocalin and matrix metalloproteinase-9 are biomarkers for the detection of tubular adenocarcinoma of colon
Manuscript Source	Unsolicited Manuscript
All Author List	Jun-Hua Yuan, Li-Shuang Xie, Yu-Hua Zhu, Xiao-Hua Wang, Yi-Jing Zhang and Xiao-Jun Wang
Funding Agency and Grant Number	Funding Agency Grant Number Shandong Key Research and Development Plan 2016GSF201020
Corresponding Author	Jun-Hua Yuan, MD, Chief Physician, Department of Geriatric Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324 Jingwu Weiqi Road, Huaiyin District, Jinan 250021, Shandong Province, China. yjh717299@126.com
Key Words	Tubular adenocarcinoma; Colon; Neutrophil gelatinase-associated lipocalin; Matrix metalloproteinase-9; Biomarker
Core Tip	Neutrophil gelatinase-associated lipocalin (NGAL) is a secreted protein, which modulates the expression of matrix metalloproteinase-9 (MMP-9) and appears in various cancers. However, it has not been explored whether NGAL or MMP-9 could be used as biomarkers in diagnosis of tubular adenocarcinoma of colon. In the present study, we demonstrated that both NGAL and MMP-9 could be used as biomarkers for diagnosis of tubular adenocarcinoma of the colon. By employing them together, the diagnosis accuracy can be further improved.
Citation	Yuan JH, Xie LS, Zhu YH, Wang XH, Zhang YJ, Wang XJ. Combination of neutrophil gelatinase-associated lipocalin and matrix metalloproteinase-9 are biomarkers for the detection of colon tubular adenocarcinoma. World J Gastrointest Oncol 2021; 13(10): 1506-1517

Received	2021-03-11 12:09
Peer-Review Started	2021-02-23 09:52
To Make the First Decision
Return for Revision	2021-04-19 02:49
Revised	2021-04-22 13:47
Second Decision	2021-07-21 03:30
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-07-21 08:43
Articles in Press	2021-07-21 08:43
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-08-25 08:14
Typeset the Manuscript	2021-10-09 03:34

ISSN	1948-5204 (online)
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