Publication Name	World Journal of Gastroenterology
Manuscript ID	63458
Country	United States

Category	Gastroenterology & Hepatology
Manuscript Type	Evidence Review
Article Title	Role of microbial dysbiosis in the pathogenesis of esophageal mucosal disease: A paradigm shift from acid to bacteria?
Manuscript Source	Invited Manuscript
All Author List	Steve M D'Souza, Kevin Houston, Lauren Keenan, Byung Soo Yoo, Parth J Parekh and David A Johnson
Funding Agency and Grant Number
Corresponding Author	David A Johnson, FACP, FASGE, MD, N/A, Doctor, Professor, Department of Internal Medicine, Division of Gastroenterology, Eastern Virginia Medical School, 885 Kempsville Rd, Suite 114, Norfolk, VA 23502, United States. dajevms@aol.com
Key Words	Microbiome; Gastroesophageal reflux disease; Probiotics; Prebiotics; Bacteriocins; Dysbiosis; Barrett’s esophagus; Esophageal cancer; Esophagitis; Eosinophilic esophagitis
Core Tip	The interactions between the gut bacteria and the immune system of the host play a key role in the pathogenesis of gastrointestinal diseases, including those impacting the esophagus. This evidence-based review brings forward the emerging data on the microbial changes related to esophageal disease. Better understanding of these data will lead to mitigation strategies for intervention and innovation.
Citation	D'Souza SM, Houston K, Keenan L, Yoo BS, Parekh PJ, Johnson DA. Role of microbial dysbiosis in the pathogenesis of esophageal mucosal disease: A paradigm shift from acid to bacteria? World J Gastroenterol 2021; 27(18): 2054-2072

Received	2021-02-02 11:47
Peer-Review Started	2021-02-02 11:56
To Make the First Decision
Return for Revision	2021-02-27 05:41
Revised	2021-03-06 13:53
Second Decision	2021-04-12 06:22
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-04-14 17:00
Articles in Press	2021-04-14 17:00
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-04-30 06:21

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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