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Publication Name World Journal of Gastroenterology
Manuscript ID 63463
Country/Territory Germany
Category Oncology
Manuscript Type Review
Article Title Stress-activated kinases as therapeutic targets in pancreatic cancer
Manuscript Source Invited Manuscript
All Author List Benno Traub, Aileen Roth, Marko Kornmann, Uwe Knippschild and Joachim Bischof
Funding Agency and Grant Number
Funding Agency Grant Number
German Research Foundation (DFG) TR1663/1-1
German Research Foundation (DFG) KN356/9-1
Else Kröner-Fresenius-Stiftung 2017_A142
Corresponding Author Uwe Knippschild, PhD, Professor, Department of General and Visceral Surgery, Ulm University Hospital, Albert-Einstein-Allee 23, Ulm 89081, Germany. uwe.knippschild@uniklinik-ulm.de
Key Words Pancreatic cancer; Stress-activated protein kinases; Mitogen-activated protein kinases; c-Jun N-terminal kinases; Casein kinase 1; Small molecule inhibitor
Core Tip Since pancreatic cancer patients are generally confronted with poor prognosis, optimized therapeutic strategies are urgently needed. To establish new treatment options, efforts in drug development have increasingly focused on targeting protein kinases. In the cellular response to various stress signals, c-Jun N-terminal kinases (JNK) and p38 kinases as well as members of the casein kinase 1 (CK1) family are of special interest. Concentrating on pancreatic carcinoma in this review, we summarize the key roles of JNK, p38, and CK1 and provide an overview of recent achievements in the development of small molecule kinase inhibitors against these kinases.
Citation Traub B, Roth A, Kornmann M, Knippschild U, Bischof J. Stress-activated kinases as therapeutic targets in pancreatic cancer. World J Gastroenterol 2021; In press
Received
2021-01-28 15:06
Peer-Review Started
2021-01-28 15:14
To Make the First Decision
Return for Revision
2021-05-02 02:06
Revised
2021-05-17 08:53
Second Decision
2021-07-20 03:28
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-07-20 09:14
Articles in Press
2021-07-20 09:14
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Ya-Juan Ma
Reviewer Code 05388624
Editorial Director
Journal Chief Editor
Company Chief Editor Jia-Ping Yan
Language Editor
Production Editor
Responsible Production Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 63463_Auto_Edited-JPY.docx
Answering Reviewers 63463-Answering reviewers.pdf
Audio Core Tip 63463-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 63463-Conflict-of-interest statement.pdf
Copyright License Agreement 63463-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 63463-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 63463-Language certificate.pdf
Peer-review Report 63463-Peer-review(s).pdf
Scientific Misconduct Check 63463-Scientific misconduct check.pdf
Scientific Editor Work List 63463-Scientific editor work list.pdf