Publication Name	World Journal of Gastroenterology
Manuscript ID	63463
Country	Germany

Category	Oncology
Manuscript Type	Review
Article Title	Stress-activated kinases as therapeutic targets in pancreatic cancer
Manuscript Source	Invited Manuscript
All Author List	Benno Traub, Aileen Roth, Marko Kornmann, Uwe Knippschild and Joachim Bischof
Funding Agency and Grant Number	Funding Agency Grant Number German Research Foundation (DFG) TR1663/1-1 German Research Foundation (DFG) KN356/9-1 Else Kröner-Fresenius-Stiftung 2017_A142
Corresponding Author	Uwe Knippschild, PhD, Professor, Department of General and Visceral Surgery, Ulm University Hospital, Albert-Einstein-Allee 23, Ulm 89081, Germany. uwe.knippschild@uniklinik-ulm.de
Key Words	Pancreatic cancer; Stress-activated protein kinases; Mitogen-activated protein kinases; c-Jun N-terminal kinases; Casein kinase 1; Small molecule inhibitor
Core Tip	Since pancreatic cancer patients are generally confronted with poor prognosis, optimized therapeutic strategies are urgently needed. To establish new treatment options, efforts in drug development have increasingly focused on targeting protein kinases. In the cellular response to various stress signals, c-Jun N-terminal kinases (JNK) and p38 kinases as well as members of the casein kinase 1 (CK1) family are of special interest. Concentrating on pancreatic carcinoma in this review, we summarize the key roles of JNK, p38, and CK1 and provide an overview of recent achievements in the development of small molecule kinase inhibitors against these kinases.
Citation	Traub B, Roth A, Kornmann M, Knippschild U, Bischof J. Stress-activated kinases as therapeutic targets in pancreatic cancer. World J Gastroenterol 2021; 27(30): 4963-4984

Received	2021-01-28 15:06
Peer-Review Started	2021-01-28 15:14
To Make the First Decision
Return for Revision	2021-05-02 02:06
Revised	2021-05-17 08:53
Second Decision	2021-07-20 03:28
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-07-20 09:14
Articles in Press	2021-07-20 09:14
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-08-06 10:29

ISSN	1007-9327 (print) and 2219-2840 (online)
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