Publication Name	World Journal of Diabetes
Manuscript ID	63533
Country	Italy

Category	Endocrinology & Metabolism
Manuscript Type	Field of Vision
Article Title	Long-term metformin therapy and vitamin B12 deficiency: An association to bear in mind
Manuscript Source	Invited Manuscript
All Author List	Marco Infante, Martina Leoni, Massimiliano Caprio and Andrea Fabbri
Funding Agency and Grant Number
Corresponding Author	Marco Infante, MD, N/A, Adjunct Professor, UniCamillus, Saint Camillus International University of Health Sciences, Via di Sant’Alessandro 8, Rome 00131, Italy. marco.infante@unicamillus.org
Key Words	Metformin; Vitamin B12 deficiency; Metformin-induced cobalamin deficiency; Diabetes; Type 2 diabetes; Prediabetes; Screening criteria; Neuropathy; Anemia
Core Tip	Over the last decades, vitamin B12 deficiency has been increasingly recognized as a possible consequence of long-term metformin therapy, potentially resulting in clinical manifestations such as hematologic abnormalities and peripheral neuropathy. Metformin-induced vitamin B12 deficiency has relevant implications in light of the growing population of individuals on metformin therapy for the treatment of type 2 diabetes, prediabetes, insulin resistance and polycystic ovary syndrome on a global scale. Notwithstanding, no definite guidelines are currently available for vitamin B12 deficiency screening in metformin-treated patients. We therefore propose a list of criteria for a cost-effective vitamin B12 deficiency screening in metformin-treated patients.
Citation	Infante M, Leoni M, Caprio M, Fabbri A. Long-term metformin therapy and vitamin B12 deficiency: An association to bear in mind. World J Diabetes 2021; 12(7): 916-931

Received	2021-01-29 00:15
Peer-Review Started	2021-01-29 00:18
To Make the First Decision
Return for Revision	2021-03-16 06:35
Revised	2021-03-21 16:50
Second Decision	2021-04-29 09:04
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-04-29 11:34
Articles in Press	2021-04-29 11:34
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-05-27 19:40
Typeset the Manuscript	2021-06-15 02:28

ISSN	1948-9358 (online)
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