Publication Name	World Journal of Clinical Cases
Manuscript ID	63738
Country	China

Category	Immunology
Manuscript Type	Opinion Review
Article Title	Regulating monocyte infiltration and differentiation: Provide new therapies for colorectal cancer patients with COVID-19
Manuscript Source	Invited Manuscript
All Author List	Ling Bai, Wang Yang, Lei Qian and Jiu-Wei Cui
Funding Agency and Grant Number	Funding Agency Grant Number the National Key Research and Development Program of New Coronary Pneumonia and Other Infectious Diseases Prevention Basic Research Orientation Project of China 2020YFA0707704 the Ministry of Science and Technology of the People’s Republic of China 2016YFC1303804 the Interdisciplinary Research Funding Program of Jilin University 101832020DJX083 the outstanding Talent Cultivation Program for Doctoral Students in Norman Bethune Health Science Center of Jilin University -
Corresponding Author	Jiu-Wei Cui, MD, PhD, Chief Doctor, Professor, Cancer Center, The First Hospital of Jilin University, No. 71 Xinmin Street, Changchun 130021, Jilin Province, China. cuijw@jlu.edu.cn
Key Words	COVID-19; SARS-CoV-2; Monocyte; Macrophage; Colorectal cancer
Core Tip	Not only colorectal cancer (CRC) is susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but its infiltrating monocytes are also affected by SARS-CoV-2. Moreover, after infection, due to the promotion of infiltration and differentiation of monocytes, CRC patients are more likely to develop severe coronavirus disease 2019 (COVID-19). In severe COVID-19, due to the activation of NF-κB and CCR5 signaling pathways, the imbalance of macrophage polarization can further cause the aggravation of cytokine release syndrome.
Citation	Bai L, Yang W, Qian L, Cui JW. Regulating monocyte infiltration and differentiation: Provide new therapies for colorectal cancer patients with COVID-19. World J Clin Cases 2021; 9(34): 10392-10399

Received	2021-02-01 16:13
Peer-Review Started	2021-02-01 16:42
To Make the First Decision
Return for Revision	2021-03-30 23:51
Revised	2021-05-10 07:46
Second Decision	2021-08-04 03:32
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-08-04 07:00
Articles in Press	2021-08-04 07:00
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-10-21 04:54
Typeset the Manuscript	2021-11-24 02:50

ISSN	2307-8960 (online)
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