Publication Name	World Journal of Clinical Cases
Manuscript ID	63807
Country	Japan

Category	Transplantation
Manuscript Type	Case Report
Article Title	Maintenance treatment with infliximab for ulcerative ileitis after intestinal transplantation: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Takumi Fujimura, Yohei Yamada, Tomoshige Umeyama, Yumi Kudo, Hiroki Kanamori, Teizaburo Mori, Takahiro Shimizu, Mototoshi Kato, Miho Kawaida, Naoki Hosoe, Yasushi Hasegawa, Kentaro Matsubara, Naoki Shimojima, Masahiro Shinoda, Hideaki Obara, Makoto Naganuma, Yuko Kitagawa, Ken Hoshino and Tatsuo Kuroda
Funding Agency and Grant Number	Funding Agency Grant Number JSPS KAKENHI JP18K16286 JSPS KAKENHI JP18K08600
Corresponding Author	Yohei Yamada, FACS, MD, PhD, Assistant Lecturer, Department of Pediatric Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. yohei.z7@keio.jp
Key Words	Intestinal transplantation; Chronic ulcer; Infliximab; Crohn’s disease; Tumor necrosis factor alpha; Case report
Core Tip	Infliximab binds to soluble and transmembrane forms of human tumor necrosis factor alpha (TNF-α). Ulcerative inflammatory changes in the graft under intestinal transplantation (ITx) is an often-encountered finding. However, it does not meet the criteria for so-called rejection and is close to the pathology of Crohn's disease. Studies in Crohn’s disease patients revealed that anti-TNF-α therapy provides better outcomes when combined with immunomodulatory agents and that therapeutic drug monitoring might help optimize dosing. Infliximab may be effective as a treatment for ulcerative inflammation that does not meeting the criteria for acute cell rejection not improved by immunosuppressant conditioning. The optimal management for recurrent ulcerative inflammation under ITx settings by using anti-TNF-α therapy needs further elucidation.
Citation	Fujimura T, Yamada Y, Umeyama T, Kudo Y, Kanamori H, Mori T, Shimizu T, Kato M, Kawaida M, Hosoe N, Hasegawa Y, Matsubara K, Shimojima N, Shinoda M, Obara H, Naganuma M, Kitagawa Y, Hoshino K, Kuroda T. Maintenance treatment with infliximab for ulcerative ileitis after intestinal transplantation: A case report. World J Clin Cases 2021; 9(19): 5270-5279

Received	2021-02-03 03:10
Peer-Review Started	2021-02-03 03:20
To Make the First Decision
Return for Revision	2021-03-06 07:51
Revised	2021-03-18 21:19
Second Decision	2021-05-17 06:58
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-05-17 11:55
Articles in Press	2021-05-17 11:55
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-06-03 00:18

ISSN	2307-8960 (online)
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