Publication Name	World Journal of Psychiatry
Manuscript ID	63863
Country	Germany

Category	Neurosciences
Manuscript Type	Review
Article Title	Polyamines and polyamine-metabolizing enzymes in schizophrenia: Current knowledge and concepts of therapy
Manuscript Source	Invited Manuscript
All Author List	Hans-Gert Bernstein, Gerburg Keilhoff, Gregor Laube, Henrik Dobrowolny and Johann Steiner
Funding Agency and Grant Number
Corresponding Author	Hans-Gert Bernstein, PhD, Emeritus Professor, Department of Psychiatry, University of Magdeburg, Leipziger Str. 44, Magdeburg D-39116, Saxony-Anhalt, Germany. hans-gert.bernstein@med.ovgu.de
Key Words	Polyamines; Spermidine; Spermine; Schizophrenia; Animal models; Therapy
Core Tip	This review summarizes the advancements in research on the implications of polyamines and their metabolites for schizophrenia. Evidence from clinical and experimental studies show that some members of the polyamine regulatory system are altered in schizophrenia, but no polyamine-based therapy for schizophrenia is currently available.
Citation	Bernstein HG, Keilhoff G, Laube G, Dobrowolny H, Steiner J. Polyamines and polyamine-metabolizing enzymes in schizophrenia: Current knowledge and concepts of therapy. World J Psychiatr 2021; 11(12): 1177-1190

Received	2021-02-04 10:30
Peer-Review Started	2021-02-04 10:37
To Make the First Decision
Return for Revision	2021-04-21 00:18
Revised	2021-04-30 08:54
Second Decision	2021-11-22 03:35
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-11-25 02:47
Articles in Press	2021-11-25 02:47
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-11-17 04:04
Typeset the Manuscript	2021-11-29 08:38

ISSN	2220-3206 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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