Publication Name	World Journal of Clinical Cases
Manuscript ID	63923
Country	China

Category	Toxicology
Manuscript Type	Observational Study
Article Title	Early diagnosis, treatment, and outcomes of five patients with acute thallium poisoning
Manuscript Source	Unsolicited Manuscript
All Author List	Ting-Ting Wang, Bing Wen, Xiu-Nan Yu, Zhang-Ge Ji, Yi-Yong Sun, Ying Li, Shou-Lian Zhu, Yong-Liang Cao, Mei Wang, Xiang-Dong Jian and Tan Wang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81701058 Shandong Academy of Sciences ZR2017PH027 China Postdoctoral Science Foundation 2017M612288
Corresponding Author	Tan Wang, MD, PhD, Professor, Department of Geriatrics, Qilu hospital of Shandong University, No. 107 West Wenhua Road, Jinan 250012, Shandong Province, China. olivelwang@sdu.edu.cn
Key Words	Thallium poisoning; Hyperalgesia; Abdominalgia; Hemoperfusion; Prussian blue; Outcomes
Core Tip	Thallium poisoning is rare and easily to be misdiagnosed. In this study, dysesthesia of limbs with hyperalgesia and abdominalgia were the main initial symptoms of the five patients who had a thallium-contaminating meal together. The diagnosis was confirmed by high thallium concentrations in the blood and urine samples which were detected 8 to 12 d after exposure. We found that early treatment with the combination of hemoperfusion and Prussian blue significantly decreased the concentration of thallium in the body and improved the prognosis. Our study provided valuable experiences on early diagnosis and therapeutic regimen for thallium-poisoned patients.
Citation	Wang TT, Wen B, Yu XN, Ji ZG, Sun YY, Li Y, Zhu SL, Cao YL, Wang M, Jian XD, Wang T. Early diagnosis, treatment, and outcomes of five patients with acute thallium poisoning. World J Clin Cases 2021; 9(19): 5082-5091

Received	2021-02-06 04:38
Peer-Review Started	2021-02-06 04:43
To Make the First Decision
Return for Revision	2021-03-25 05:19
Revised	2021-03-27 10:34
Second Decision	2021-05-17 07:29
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-05-17 11:53
Articles in Press	2021-05-17 11:53
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-05-24 02:35
Typeset the Manuscript	2021-06-16 11:14

ISSN	2307-8960 (online)
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