Publication Name	World Journal of Hepatology
Manuscript ID	64130
Country	Brazil

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Six-minute walking test performance is associated with survival in cirrhotic patients
Manuscript Source	Unsolicited Manuscript
All Author List	Carolina Frade M G Pimentel, Ana Cristina de Castro Amaral, Adriano Miziara Gonzalez, Michelle Lai, Daniel de Oliveira Mota, Maria Lucia Gomes Ferraz, Wilson Mathias Junior and Mario Kondo
Funding Agency and Grant Number
Corresponding Author	Carolina Frade M G Pimentel, MD, Professor, Department of Medicine, Federal University of Sao Paulo, Botucatu Street n 740, Sao Paulo 04026090, Brazil. carolinapimentel.gastro@gmail.com
Key Words	Six-minute walking test; Liver cirrhosis; Hospital admission and mortality; Child score
Core Tip	Our study proposes that six-minute walking test, a simple exercise test, can be applicable in the evaluation of cirrhotic patients. This is a well-none routine assessment in patients with cardiopulmonary diseases, where it is used to predict mortality in this population. Its use in liver cirrhosis is limited. Patients with chronic hepatic insufficient are at risk of progressively muscle loss, frailty, and exercise limitation, all factors directly associated with poor survival. We propose by using six-minute walk test a practical and simple manner of assess this risks and provide a better understanding of how exercise limitation can directly affect survival.
Citation	Pimentel CFMG, Amaral ACC, Gonzalez AM, Lai M, Mota DO, Ferraz MLG, Junior WM, Kondo M. Six-minute walking test performance is associated with survival in cirrhotic patients. World J Hepatol 2021; 13(11): 1791-1801

Received	2021-02-09 13:14
Peer-Review Started	2021-02-09 13:14
To Make the First Decision
Return for Revision	2021-05-13 22:07
Revised	2021-05-18 12:44
Second Decision	2021-10-11 08:28
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-10-14 03:03
Articles in Press	2021-10-14 03:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-11-19 01:14

ISSN	1948-5182 (online)
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