Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	64238
Country	China

Category	Transplantation
Manuscript Type	Scientometrics
Article Title	Immunotherapy after liver transplantation: Where are we now?
Manuscript Source	Invited Manuscript
All Author List	Kin Pan Au and Kenneth Siu Ho Chok
Funding Agency and Grant Number
Corresponding Author	Kenneth Siu Ho Chok, FACS, FRCS (Ed), MBBS, MD, MS, Associate Professor, Department of Surgery and State Key Laboratory for Liver Research, The University of Hong Kong, 102 Pok Fu Lam Road, Hong Kong NA, China. kennethchok@gmail.com
Key Words	Liver transplant; Hepatocellular carcinoma; Recurrence; Immunotherapy; Rejection; Survival
Core Tip	A literature review was performed to identify patients with prior liver transplantation and subsequent immunotherapy. Among the 28 included patients, the rejection rate was 32% (n = 9). Patients who developed acute rejection were given immunotherapy earlier after transplantation (median 2.9 years vs 5.3 years, P = 0.02) and their graft biopsies might be more frequently programmed death ligand-1 positive (100% vs 33%, P = 0.053). Among the 19 patients treated for hepatocellular carcinoma (HCC), the overall objective response rate was 11%. Rejection risk is the major obstacle to immunotherapy for post-liver transplant HCC recurrence.
Citation	Au KP, Chok KSH. Immunotherapy after liver transplantation: Where are we now? World J Gastrointest Surg 2021; 13(10): 1267-1278

Received	2021-02-14 12:29
Peer-Review Started	2021-02-14 12:34
To Make the First Decision
Return for Revision	2021-03-16 17:14
Revised	2021-03-25 02:10
Second Decision	2021-08-04 03:34
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-08-04 09:02
Articles in Press	2021-08-04 09:02
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-08-26 03:00
Typeset the Manuscript	2021-10-19 07:31

ISSN	1948-9366 (online)
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