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10/15/2021 9:02:34 AM | Browse: 112 | Download: 127
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 64343
Country/Territory Italy
Category Oncology
Manuscript Type Minireviews
Article Title Current status of first-line therapy, anti-angiogenic therapy and its combinations of other agents for unresectable hepatocellular carcinoma
Manuscript Source Invited Manuscript
All Author List Saleh A Alqahtani and Massimo G Colombo
Funding Agency and Grant Number
Corresponding Author Massimo G Colombo, MD, Professor, Liver Center, IRCCS San Raffaele Hospital, Via Olgettina 60, Milan 20132, Italy. mcolombo46@yahoo.it
Key Words Hepatocellular carcinoma; Immune checkpoint inhibitor; Lenvatinib; Multi-tyrosine kinase inhibitor; Sorafenib
Core Tip Recently, an immunotherapy-based combination of atezolizumab and bevacizumab was shown to prolong survival compared to sorafenib in unresectable hepatocellular carcinoma (HCC) patients who did not receive prior therapy. In addition, the combination of lenvatinib and pembrolizumab has yielded promising results in the same patient setting. This review article summarizes the results obtained with sorafenib and lenvatinib in patients with unresectable HCC in pivotal clinical trials and real-world studies. We offer guidance on the optimal choice between sorafenib or lenvatinib in an individual patient and discuss the immunotherapy-based combination, which will likely make the choice between sorafenib and lenvatinib somewhat obsolete.
Citation Alqahtani SA, Colombo MG. Current status of first-line therapy, anti-angiogenic therapy and its combinations of other agents for unresectable hepatocellular carcinoma. World J Gastrointest Oncol 2021; 13(12): 2038-2049
Received
2021-02-15 14:44
Peer-Review Started
2021-02-15 14:49
To Make the First Decision
Return for Revision
2021-03-15 04:54
Revised
2021-03-24 20:55
Second Decision
2021-10-15 06:33
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-10-15 09:02
Articles in Press
2021-10-15 09:02
Publication Fee Transferred
Edit the Manuscript by Language Editor
2021-09-29 19:20
Typeset the Manuscript
2021-12-07 04:32
ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Jia-Ru Fan
Reviewer Code 01469051, 01438831, and 02438768
Editorial Director
Journal Chief Editor
Company Chief Editor Lian-Sheng Ma
Language Editor Donna Fox
Production Editor Ying-Yi Yuan
Responsible Production Editor Ying-Yi Yuan
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Full Article (PDF) WJGO-13-2038.pdf
Full Article (Word) WJGO-13-2038.docx
Manuscript File 64343_Auto_Edited-JRF-FilipodiaCL.docx
Answering Reviewers 64343-Answering reviewers.pdf
Audio Core Tip 64343-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 64343-Conflict-of-interest statement.pdf
Copyright License Agreement 64343-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 64343-Language certificate.pdf
Supplementary Material 64343-Copyright permission.pdf
Peer-review Report 64343-Peer-review(s).pdf
Scientific Misconduct Check 64343-Bing-Wang JL-1.jpg
Scientific Misconduct Check 64343-Bing-Fan JR-2.png
Scientific Editor Work List 64343-Scientific editor work list.pdf