Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	64660
Country	United States

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Application of the woodchuck animal model for the treatment of hepatitis B virus-induced liver cancer
Manuscript Source	Invited Manuscript
All Author List	Manasa Suresh and Stephan Menne
Funding Agency and Grant Number
Corresponding Author	Stephan Menne, PhD, Associate Professor, Department of Microbiology & Immunology, Georgetown University Medical Center, 3rd Floor, Medical-Dental Building, 3900 Reservoir Road, Washington, DC 20057, United States. stephan.menne@georgetown.edu
Key Words	Woodchuck; Hepatitis B virus; Chronic infection; Liver disease; Hepatocellular carcinoma; Cancer treatment
Core Tip	Hepatitis B virus-induced liver tumors are hard to treat with currently available interventions and the prognosis of hepatocellular carcinoma (HCC) in patients remains still poor. Immunocompetent woodchucks are a useful animal model for human HCC, because multiple tumors at different stages develop spontaneously and secondary to viral infection. This similarity to human hepatocarcinogenesis and the animal’s vascular architecture allowing catheterization with human-sized products have increased the preclinical use of this model to improve existing imaging (ultrasound, magnetic resonance imaging, and positron-emission tomography) and ablation techniques (embolization and radiotherapy) and to evaluate interventions (chemo, gene, and immune therapy) intended to treat human HCC.
Citation	Suresh M, Menne S. Application of the woodchuck animal model for the treatment of hepatitis B virus-induced liver cancer. World J Gastrointest Oncol 2021; 13(6): 509-535

Received	2021-02-21 20:53
Peer-Review Started	2021-02-21 20:56
To Make the First Decision
Return for Revision	2021-04-19 17:29
Revised	2021-05-02 16:34
Second Decision	2021-05-14 13:39
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-05-15 05:06
Articles in Press	2021-05-15 05:06
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-05-28 12:00

ISSN	1948-5204 (online)
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