Publication Name	World Journal of Clinical Oncology
Manuscript ID	64774
Country	Italy

Category	Oncology
Manuscript Type	Observational Study
Article Title	Modulated electro-hyperthermia in stage III and IV pancreatic cancer: Results of an observational study on 158 patients
Manuscript Source	Invited Manuscript
All Author List	Giammaria Fiorentini, Donatella Sarti, Girolamo Ranieri, Cosmo Damiano Gadaleta, Caterina Fiorentini, Carlo Milandri, Andrea Mambrini and Stefano Guadagni
Funding Agency and Grant Number
Corresponding Author	Giammaria Fiorentini, MD, Adjunct Professor, Chief Doctor, Director, Department of Onco-Hematology, Azienda Ospedaliera “Ospedali Riuniti Marche Nord”, Via Lombroso, Pesaro 61122, Italy. g.fiorentini2020@gmail.com
Key Words	Modulated electro-hyperthermia; Locally advanced pancreatic cancer; Tumor response; Survival
Core Tip	The modulated electro-hyperthermia (mEHT) is a relatively new regional hyperthermia method. It targets tumor cell membranes and extracellular matrix, to increase their temperature. New studies have appeared in tumor palliation reporting incremental benefits of chemotherapy (CHT) and radiotherapy and few additional side effects. In patients with stage III and IV pancreatic cancer mEHT in association with CHT results in significant improvements of overall and progression free survival and tumor response with comparable toxicity.
Citation	Fiorentini G, Sarti D, Ranieri G, Gadaleta CD, Fiorentini C, Milandri C, Mambrini A, Guadagni S. Modulated electro-hyperthermia in stage III and IV pancreatic cancer: Results of an observational study on 158 patients. World J Clin Oncol 2021; 12(11): 1064-1071

Received	2021-02-23 11:50
Peer-Review Started	2021-02-23 11:59
To Make the First Decision
Return for Revision	2021-05-07 20:31
Revised	2021-05-18 06:08
Second Decision	2021-09-30 04:22
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-09-30 07:58
Articles in Press	2021-09-30 07:58
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-09-27 01:29
Typeset the Manuscript	2021-11-17 06:00

ISSN	2218-4333 (online)
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