Publication Name	World Journal of Stem Cells
Manuscript ID	64854
Country	Ukraine

Category	Neurosciences
Manuscript Type	Minireviews
Article Title	Mesenchymal stem cells as a potential therapeutic tool to cure cognitive impairment caused by neuroinflammation
Manuscript Source	Invited Manuscript
All Author List	Maryna Skok
Funding Agency and Grant Number
Corresponding Author	Maryna Skok, DSc, Academic Fellow, Professor, Senior Researcher, Department of Molecular Immunology, Palladin Institute of Biochemistry NAS of Ukraine, 9 Leontovicha str., Kyiv 01054, Ukraine. skok@biochem.kiev.ua
Key Words	Mesenchymal stem cells; Neuroinflammation; Cognition; α7 Nicotinic acetylcholine receptor; Extracellular vesicles; Alzheimer disease
Core Tip	Mesenchymal stem cells (MSCs) have a significant therapeutic potential in treating neuroinflammation-related cognitive disfunctions including age-related neurodegenerative diseases. The review summarizes recent data concerning optimization of MSCs use for therapeutic purposes with the emphasis on the achievements of the last two years. Specific attention is paid to extracellular vesicles secreted by MSCs and to the role of α7 nicotinic acetylcholine receptors. The main conclusion is that therapeutic application of MSCs should include measures to facilitate their homing to the brain, support the survival in the brain microenvironment and stimulate the production of neurotrophic and anti-inflammatory factors.
Citation	Skok M. Mesenchymal stem cells as a potential therapeutic tool to cure cognitive impairment caused by neuroinflammation. World J Stem Cells 2021; 13(8): 1072-1083

Received	2021-02-24 13:06
Peer-Review Started	2021-02-24 13:09
To Make the First Decision
Return for Revision	2021-04-20 02:17
Revised	2021-04-28 09:21
Second Decision	2021-07-29 02:54
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-07-29 06:39
Articles in Press	2021-07-29 06:39
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-08-04 23:44
Typeset the Manuscript	2021-08-17 09:45

ISSN	1948-0210 (online)
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