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8/4/2021 8:13:46 AM | Browse: 54 | Download: 5
Publication Name World Journal of Psychiatry
Manuscript ID 64875
Country/Territory Germany
Category Psychiatry
Manuscript Type Minireviews
Article Title Recent advances in the treatment of opioid use disorders–focus on long-acting buprenorphine formulations
Manuscript Source Invited Manuscript
All Author List Michael Soyka and Andreas Guenter Franke
Funding Agency and Grant Number
Corresponding Author Michael Soyka, MD, Professor, Psychiatric Hospital, University of Munich, Nußbaumstr 7, München 80336, Germany. michael.soyka@outlook.de
Key Words Opioids; Opioid dependence; Maintenance treatment; Methadone; Buprenorphine; Depot; Implant
Core Tip Although opioid maintenance therapy with methadone or buprenorphine is the widely accepted first line treatment in opioid use disorders (OUDs) the risk of diversion and low retention rates limit its use. While previous attempts to introduce long-acting methadone analogues have failed due to cardiac side effects in recent years, three different long-acting buprenorphine formulations have been developed and successfully studied in opioid users, two weekly or monthly depot injections (CAM 2038, RBP-6000) and one implant (probuphine). The prospects of these new medications are significant by optimizing retention and compliance and minimizing the risk of diversion. Thus these novel medications can facilitate treatment of OUDs significantly.
Citation Soyka M, Franke AG. Recent advances in the treatment of opioid use disorders–focus on long-acting buprenorphine formulations. World J Psychiatr 2021; 11(9): 543-552
Received
2021-02-24 16:39
Peer-Review Started
2021-02-24 16:42
To Make the First Decision
Return for Revision
2021-04-21 00:12
Revised
2021-06-06 17:22
Second Decision
2021-08-04 03:34
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-08-04 08:13
Articles in Press
2021-08-04 08:13
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2021-09-10 15:05
ISSN 2220-3206 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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