Publication Name	World Journal of Hepatology
Manuscript ID	64891
Country	Germany

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Fatty acid metabolism and acyl-CoA synthetases in the liver-gut axis
Manuscript Source	Invited Manuscript
All Author List	Yunxia Ma, Miljana Nenkov, Yuan Chen, Adrian T Press, Elke Kaemmerer and Nikolaus Gassler
Funding Agency and Grant Number	Funding Agency Grant Number Interdisziplinäres Zentrum für Klinische Forschung of University Hospital Jena IZKF-MSP-06
Corresponding Author	Nikolaus Gassler, MA, MD, Professor, Section Pathology, Institute of Forensic Medicine, Jena University Hospital, Friedrich Schiller University Jena, Am Klinikum 1, Jena 07747, Germany. nikolaus.gassler@med.uni-jena.de
Key Words	Long-chain fatty acids; Short-chain fatty acids; Acyl-CoA synthetases; Microbiota; Liver-gut axis
Core Tip	To understand the role of acyl-CoA synthetases (ACSs) in the fatty acid metabolism, it is necessary to explore the biological function, gene interactions/ regulations and signal pathways in physiological and pathological conditions. Growing evidence demonstrates that the control of microbial balance plays an important role in maintaining homeostasis and normal functions of the liver-gut axis, and the bidirectional communication in turn affects microbial communities. As novel therapeutic targets, miRNAs are receiving more and more attention, together with other compounds targeting ACSs.
Citation	Ma Y, Nenkov M, Chen Y, Press AT, Kaemmerer E, Gassler N. Fatty acid metabolism and acyl-CoA synthetases in the liver-gut axis. World J Hepatol 2021; 13(11): 1512-1533

Received	2021-02-25 14:28
Peer-Review Started	2021-02-25 14:33
To Make the First Decision
Return for Revision	2021-06-15 22:20
Revised	2021-06-28 12:24
Second Decision	2021-10-08 03:30
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-10-11 01:20
Articles in Press	2021-10-11 01:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-11-19 01:04

ISSN	1948-5182 (online)
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