Publication Name	World Journal of Diabetes
Manuscript ID	65018
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Minireviews
Article Title	Metabolically healthy obesity: Is it really healthy for type 2 diabetes mellitus?
Manuscript Source	Invited Manuscript
All Author List	Qi Wu, Ming-Feng Xia and Xin Gao
Funding Agency and Grant Number	Funding Agency Grant Number Shanghai Municipal Science and Technology Major Project 2017SHZDZX01
Corresponding Author	Ming-Feng Xia, MD, Associate Professor, Attending Doctor, Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai 200032, China. dr_xiamingfeng@163.com
Key Words	Metabolically healthy obesity; Type 2 diabetes; Non-alcoholic fatty liver diseases; Insulin resistance; Low-grade inflammatory status; Beta-cell dysfunction
Core Tip	Metabolically healthy obese individuals have already developed impaired insulin sensitivity with dysfunction of insulin action on subcutaneous tissue, as well as a tendency for beta-cell dysfunction and a chronic low-grade inflammatory status compared with metabolically healthy normal-weight individuals. Thus, it is an unfavorable phenotype for type 2 diabetes, with metabolic changes preceding the incidence of diabetes. Liver fat content might be an important contributor to the development of diabetes in metabolically healthy obesity among all risk factors. More attention should be paid to the weight management and metabolic status of these individuals.
Citation	Wu Q, Xia MF, Gao X. Metabolically healthy obesity: Is it really healthy for type 2 diabetes mellitus? World J Diabetes 2022; 13(2): 70-84

Received	2021-02-26 13:38
Peer-Review Started	2021-02-26 13:45
To Make the First Decision
Return for Revision	2021-04-20 18:38
Revised	2021-04-27 10:23
Second Decision	2022-01-19 03:57
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-01-20 05:34
Articles in Press	2022-01-20 05:34
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-01-08 21:43
Typeset the Manuscript	2022-01-27 08:02

ISSN	1948-9358 (online)
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