Publication Name	World Journal of Clinical Oncology
Manuscript ID	65021
Country	Italy

Category	Oncology
Manuscript Type	Minireviews
Article Title	Chemotherapy-induced neurotoxicity in the treatment of gynecological cancers: State of art and an innovative approach for prevention
Manuscript Source	Invited Manuscript
All Author List	Ester Oneda, Chiara Abeni, Laura Zanotti, Elisabetta Zaina, Sara Bighè and Alberto Zaniboni
Funding Agency and Grant Number
Corresponding Author	Ester Oneda, MD, Doctor, Department of Clinical Oncology, Fondazione Poliambulanza, Via Bissolati 57, Brescia 25124, Italy. dott.ester.oneda@gmail.com
Key Words	Peripheral neuropathy; Ovarian cancer; Paclitaxel; Chemotherapy-induced peripheral neuropathy prevention; Hilotherapy
Core Tip	The association of carboplatin and paclitaxel is the standard chemotherapy regimen for ovarian cancer women. One of the most common and disabling side effect of this treatment is the peripheral neuropathy caused by paclitaxel, it can occur in 20% of patients and can last months and even years after the end of chemotherapy. In this review we collected the evidence from several studies with different schedules or formulation of paclitaxel and the systems of prevention and propose a mechanical way of prevention adopted in our center through the use of the cooling system of the hilotherm device.
Citation	Oneda E, Abeni C, Zanotti L, Zaina E, Bighè S, Zaniboni A. Chemotherapy-induced neurotoxicity in the treatment of gynecological cancers: State of art and an innovative approach for prevention. World J Clin Oncol 2021; 12(6): 458-467

Received	2021-02-26 14:07
Peer-Review Started	2021-02-26 14:09
To Make the First Decision
Return for Revision	2021-04-27 05:09
Revised	2021-04-29 09:42
Second Decision	2021-06-04 07:52
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-06-04 10:07
Articles in Press	2021-06-04 10:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-06-15 23:44

ISSN	2218-4333 (online)
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