Publication Name	World Journal of Hepatology
Manuscript ID	65166
Country	Greece

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Serum zonulin levels in patients with liver cirrhosis: Prognostic implications
Manuscript Source	Invited Manuscript
All Author List	Theodoros A Voulgaris, Dimitrios Karagiannakis, E Hadziyannis, Spilios Manolakopoulos, Georgios P Karamanolis, George Papatheodoridis and John Vlachogiannakos
Funding Agency and Grant Number
Corresponding Author	John Vlachogiannakos, MD, PhD, Professor, Academic Department of Gastroenterology and Hepatology, Medical School of National and Kapodistrian University of Athens, General Hospital of Athens “Laiko”, 17 Agiou Thoma Street, Athens 11527, Greece. jvlachog@hotmail.com
Key Words	Zonulin; Cirrhosis; Intestinal barrier; Bacterial translocation; Decompensation; Permeability
Core Tip	Zonulin is a protein that appears to play a significant role in gut barrier integrity. Increased zonulin levels and deregulation of intestinal permeability have been demonstrated in patients suffering from celiac disease or type 2 diabetes. However, the role of zonulin as a promoting factor of intestinal barrier disruption in patients with liver cirrhosis has not been studiedadequately. We evaluated serum zonulin levels in patients with different stages of advanced liver disease. According to our findings, serum zonulin levels are increased in patients with more advanced liver disease and are independently associated with progression to decompensation.
Citation	Voulgaris TA, Karagiannakis D, Hadziyannis E, Manolakopoulos S, Karamanolis GP, Papatheodoridis G, Vlachogiannakos J. Serum zonulin levels in patients with liver cirrhosis: Prognostic implications. World J Hepatol 2021; 13(10): 1394-1404

Received	2021-02-28 20:51
Peer-Review Started	2021-02-28 21:00
To Make the First Decision
Return for Revision	2021-05-02 23:49
Revised	2021-05-12 16:42
Second Decision	2021-09-17 03:30
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-09-19 09:05
Articles in Press	2021-09-19 09:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-10-20 01:26

ISSN	1948-5182 (online)
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