Publication Name	World Journal of Clinical Oncology
Manuscript ID	65224
Country	Spain

Category	Oncology
Manuscript Type	Review
Article Title	Management of genitourinary syndrome of menopause in breast cancer survivors: An update
Manuscript Source	Invited Manuscript
All Author List	Daniel María Lubián López
Funding Agency and Grant Number
Corresponding Author	Daniel María Lubián López, MD, PhD, Full Professor, Department of Mother and Child Health and Radiology, Faculty of Medicine.University of Cadiz, Service of Obstetrics and Gynecology, University Hospital of Puerto Real, Cádiz, Spain 11510. dmlulo@gmail.com, Cádiz 11100, Cádiz, Spain. dmlulo@gmail.com
Key Words	Genitourinary syndrome of menopause; Breast cancer survivors; Aromatase inhibitors; Vaginal moisturizers and lubricants; Vaginal estrogens; Laser
Core Tip	Genitourinary syndrome of menopause (GSM) is commonly experienced by breast cancer survivors (BCSs) receiving antiestrogen therapy, specifically aromatase inhibitors. Vaginal dryness, itching, irritation and dyspareunia produce impairment of sexual function and negatively impact on the quality of life. Healthy women, and even more so BCSs, are reluctant to discuss this problem with their general practitioner or oncologist. Safety of vaginal estrogen therapy for management of GSM refractory to other nonhormonal treatment in BCSs has not been definitively established, and recommendations for use remain controversial. This review aims to summarize the clinical approach and emerging therapeutic alternatives, considering the efficacy and potencial adverse effects in this population.
Citation	Lubián López DM. Management of genitourinary syndrome of menopause in breast cancer survivors: An update. World J Clin Oncol 2022; 13(2): 71-100

Received	2021-03-01 21:02
Peer-Review Started	2021-03-01 21:06
To Make the First Decision
Return for Revision	2021-09-02 02:10
Revised	2021-09-19 22:50
Second Decision	2022-01-17 05:42
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-01-20 05:33
Articles in Press	2022-01-20 05:33
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-02-16 13:51

ISSN	2218-4333 (online)
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