Publication Name	World Journal of Gastroenterology
Manuscript ID	65273
Country	Brazil

Category	Transplantation
Manuscript Type	Minireviews
Article Title	Machine perfusion of the liver: Putting the puzzle pieces together
Manuscript Source	Invited Manuscript
All Author List	Yuri L Boteon, Paulo N Martins, Paolo Muiesan and Andrea Schlegel
Funding Agency and Grant Number
Corresponding Author	Yuri L Boteon, MD, PhD, Doctor, Professor, Surgeon, Liver Unit, Hospital Israelita Albert Einstein, Jardim Leonor, São Paulo 05652-900, São Paulo, Brazil. yuri.boteon@einstein.br
Key Words	Machine perfusion of the liver; Liver transplantation; Organ donation; Extended criteria donors; Liver preservation; Clinical trials
Core Tip	The frequent use of extended criteria donor organs unveiled the limits of static cold storage and created the conditions for the renewed interest in dynamic organ preservation. Indeed, several studies have suggested the superiority of this method over static cold storage for these high-risk donors. However, controversy still exists between different machine perfusion modalities and even amongst studies employing the same method, compromising the strength of the available evidence. With the currently fragmented efforts, the development of collaborative networks will produce collective outcomes that will expand the boundaries of current knowledge.
Citation	Boteon YL, Martins PN, Muiesan P, Schlegel A. Machine perfusion of the liver: Putting the puzzle pieces together. World J Gastroenterol 2021; 27(34): 5727-5736

Received	2021-03-02 21:53
Peer-Review Started	2021-03-02 22:05
To Make the First Decision
Return for Revision	2021-04-17 14:15
Revised	2021-05-03 16:52
Second Decision	2021-07-21 03:30
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-07-21 07:59
Articles in Press	2021-07-21 07:59
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-08-14 07:16
Typeset the Manuscript	2021-09-02 03:50

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com