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9/10/2021 9:30:27 AM | Browse: 49 | Download: 24
Publication Name World Journal of Hepatology
Manuscript ID 65350
Country/Territory Uruguay
Category Virology
Manuscript Type Review
Article Title In the era of rapid mRNA-based vaccines: Why is there no effective hepatitis C virus vaccine yet?
Manuscript Source Invited Manuscript
All Author List Natalia Echeverría, Victoria Comas, Fabián Aldunate, Paula Perbolianachis, Pilar Moreno and Juan Cristina
Funding Agency and Grant Number
Funding Agency Grant Number
Programa de Desarrollo de las Ciencias Básicas (PEDECIBA)
Comisión Académica de Posgrados, Universidad de la República Uruguay (UdelaR)
Comisión Sectorial de Investigación Científica (CSIC, I+D Project ID288)
Corresponding Author Juan Cristina, PhD, Full Professor, Laboratorio de Virología Molecular, Centro de Investigaciones Nucleares, Facultad de Ciencias, Universidad de la República, Mataojo 2055, Montevideo 11400, Uruguay. cristina@cin.edu.uy
Key Words Hepatitis C virus; Vaccine candidates; Nucleic acid-based vaccines; Recombinant vector-based vaccines; Challenges
Core Tip Hepatitis C virus (HCV) remains a global health burden despite the successful introduction of direct-acting antiviral therapies. In order to achieve global control of HCV epidemic a vaccine is necessary. Its development has faced many hurdles, reason why it is still elusive. Herein, we describe all the challenges during HCV vaccine research, focusing on HCV immunology and emphasizing on current vaccine candidates, particularly nucleic acid-based as well as recombinant vector-based vaccines. We also highlight the impact of severe acute respiratory syndrome coronavirus-2 vaccine race on the renewed interest on HCV vaccine production. Finally, we present ideas on live-attenuated vaccine approaches against HCV.
Citation Echeverría N, Comas V, Aldunate F, Perbolianachis P, Moreno P, Cristina J. In the era of rapid mRNA-based vaccines: Why is there no effective hepatitis C virus vaccine yet? World J Hepatol 2021; In press
Received
2021-03-04 21:56
Peer-Review Started
2021-03-04 22:04
To Make the First Decision
Return for Revision
2021-05-02 23:42
Revised
2021-05-14 22:40
Second Decision
2021-09-09 03:22
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-09-10 09:30
Articles in Press
2021-09-10 09:30
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1948-5182 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Jia-Ru Fan
Reviewer Code 04417620, and 03475479
Editorial Director
Journal Chief Editor
Company Chief Editor Lian-Sheng Ma
Language Editor
Production Editor
Responsible Production Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 65350_Auto_Edited.docx
Answering Reviewers 65350-Answering reviewers.pdf
Audio Core Tip 65350-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 65350-Conflict-of-interest statement.pdf
Copyright License Agreement 65350-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 65350-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 65350-Language certificate.pdf
Peer-review Report 65350-Peer-review(s).pdf
Scientific Misconduct Check 65350-Bing-Wang JL-1.jpg
Scientific Misconduct Check 65350-Bing-Fan JR-2.png
Scientific Editor Work List 65350-Scientific editor work list.pdf