Publication Name	World Journal of Clinical Cases
Manuscript ID	65564
Country	China

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Clinical Trials Study
Article Title	Effect of exercise training on left ventricular remodeling in patients with myocardial infarction and possible mechanisms
Manuscript Source	Unsolicited Manuscript
All Author List	Meng Cai, Lei Wang and Yan-Long Ren
Funding Agency and Grant Number	Funding Agency Grant Number Beijing Hospitals Authority Youth Program QML20200604 Beijing Municipal Health Commission (No.17-3) and the Beijing Natural Science Foundation 7184205 Beijing Hospitals Authority Incubating Program PZ2021007;
Corresponding Author	Yan-Long Ren, MD, Professor, Surgeon, Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, No. 2 Anzhen Road, Beijing 100029, China. renyanlong@yeah.net
Key Words	Myocardial infarction; Rehabilitation; Exercise training; Ventricular remodeling; Matrix metallopeptidase 9; Tissue inhibitor of metalloproteinases 1
Core Tip	Exercise training (ET) under supervision based on home condition in early and recovery stage of acute myocardial infarction can improve exercise cardiopulmonary function and prevent the left ventricular remodeling. And there was no negative effect on left ventricular ejection fraction. Therefore, it may reduce unfavorable remodeling response by decreasing the levels of plasma matrix metallopeptidase 9 (MMP-9) and tissue inhibitor of metalloproteinases 1 (TIMP-1) and adjusting the ratio of MMP-9 to TIMP-1 hereafter.
Citation	Cai M, Wang L, Ren YL. Effect of exercise training on left ventricular remodeling in patients with myocardial infarction and possible mechanisms. World J Clin Cases 2021; 9(22): 6308-6318

Received	2021-04-08 08:34
Peer-Review Started	2021-04-08 08:34
To Make the First Decision
Return for Revision	2021-04-28 02:20
Revised	2021-05-12 07:02
Second Decision	2021-06-07 12:59
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-06-07 13:17
Articles in Press	2021-06-07 13:17
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-06-16 03:25
Typeset the Manuscript	2021-07-22 01:48

ISSN	2307-8960 (online)
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