Publication Name	World Journal of Clinical Oncology
Manuscript ID	65760
Country	Brazil

Category	Oncology
Manuscript Type	Review
Article Title	Systems biology and OMIC data integration to understand gastrointestinal cancers
Manuscript Source	Invited Manuscript
All Author List	Iasmin Moreira Costa Bispo, Henry Paul Granger, Palloma Porto Almeida, Patricia Belini Nishiyama and Leandro Martins de Freitas
Funding Agency and Grant Number
Corresponding Author	Leandro Martins de Freitas, BSc, MSc, PhD, Professor, Núcleo de Biointegração, Universidade Federal da Bahia, Núcleo de Biointegração, Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, Vitória da Conquista, Brazil, Vitória da Conquista 45.029-094, Bahia, Brazil. leandromartins@ufba.br
Key Words	© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Core Tip	We highlight the genomic mutations and cellular pathways in gastrointestinal (GI) cancers. These are responsible for the cell’s behavior, allowing unlimited cell replication and invasion of other tissues. Using the STRING database, we found that Akt1, catenin beta 1, E1A binding protein p300, tumor protein p53 (TP53), and TP53 binding protein 1 are central nodes in the GI cancer protein network. Their expression is associated with poor survival in some GI cancers, which was confirmed by the Kaplan Meier plotter database. This information points to crucial and shared aspects of the most frequent GI cancers.
Citation	Bispo IMC, Granger HP, Almeida PP, Nishiyama PB, de Freitas LM. Systems biology and OMIC data integration to understand gastrointestinal cancers. World J Clin Oncol 2022; 13(10): 762-778

Received	2021-03-16 00:42
Peer-Review Started	2021-03-16 01:12
To Make the First Decision
Return for Revision	2021-04-27 03:49
Revised	2021-05-22 00:21
Second Decision	2022-09-26 03:46
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-10-03 03:56
Articles in Press	2022-10-03 03:56
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-09-20 19:57
Typeset the Manuscript	2022-10-13 07:11

ISSN	2218-4333 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	Gastrointestinal cancers; Genome; Cellular pathways; Protein-protein interaction; Prognosis; OMIC data
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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