Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	65892
Country	South Korea

Category	Biochemistry & Molecular Biology
Manuscript Type	Editorial
Article Title	Inhibition of poly (ADP-Ribose) polymerase: A promising strategy targeting pancreatic cancer with BRCAness phenotype
Manuscript Source	Invited Manuscript
All Author List	Keun-Yeong Jeong and Haejun Lee
Funding Agency and Grant Number
Corresponding Author	Keun-Yeong Jeong, PhD, Executive Vice President, Research Assistant Professor, R&D Center, Metimedi Pharmaceuticals, 263 Central ro, Incheon 22006, South Korea. alvirus@naver.com
Key Words	Pancreatic cancer; BRCAness; Poly (ADP-Ribose) polymerase-1; PARylation; Poly (ADP-Ribose) polymerase-1 inhibitor
Core Tip	The incidence of germline mutations of the breast cancer susceptibility gene (BRCA), defined as BRCAness, that can be targeted for pancreatic cancer is 9%-17%. Mutations in BRCAs are responsible for causing genetic instability and worsening the prognosis. Therefore, inhibition of poly (ADP-Ribose) polymerase-1 has emerged as a promising therapeutic target for BRCAness pancreatic cancer within the framework of an increase in genome instability.
Citation	Jeong KY, Lee H. Inhibition of poly (ADP-Ribose) polymerase: A promising strategy targeting pancreatic cancer with BRCAness phenotype. World J Gastrointest Oncol 2021; 13(11): 1544-1550

Received	2021-03-17 12:30
Peer-Review Started	2021-03-17 12:35
To Make the First Decision
Return for Revision	2021-04-19 02:39
Revised	2021-04-20 04:45
Second Decision	2021-09-09 03:22
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-09-10 09:23
Articles in Press	2021-09-10 09:23
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-11-09 08:11

ISSN	1948-5204 (online)
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