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Publication Name World Journal of Cardiology
Manuscript ID 66147
Country/Territory United Kingdom
Category Cardiac and Cardiovascular Systems
Manuscript Type Minireviews
Article Title Intensive lipid-lowering therapy, time to think beyond low-density lipoprotein cholesterol
Manuscript Source Invited Manuscript
All Author List Ahmed Abdalwahab, Ayman Al-atta, Azfar Zaman and Mohammad Alkhalil
Funding Agency and Grant Number
Corresponding Author Mohammad Alkhalil, DPhil, MRCP, Doctor, Cardiothoracic Centre, Freeman Hospital, Freeman Road, Newcastle upon Tyne NE7 7DN, United Kingdom. mak-83@hotmail.com
Key Words Intensive lipid-lowering; Proprotein convertase subtilisin kexin 9 inhibitors; Ezetimibe; Plaque imaging; Low-density lipoprotein cholesterol
Core Tip Intensive lipid-lowering therapies using ezetimibe and more recently proprotein convertase subtilisin kexin 9 inhibitors have improved clinical outcomes. Unselective application of these treatments is undesirable and unaffordable and, therefore, has been guided by low-density lipoprotein cholesterol level. Nonetheless, the residual risk in the post-statin era is markedly heterogeneous. Emerging data show that intensive lipid-lowering therapy produce larger absolute risk reduction in patients with polyvascular disease, post coronary artery bypass graft and diabetes. Notably, these clinical entities share similar phenotype of large burden of atherosclerotic plaques. Novel plaque imaging may aid decision making by identifying patients with propensity to develop lipid rich plagues at multi-vascular sites. Those patients may be suitable candidates for intensive lipid lowering treatment.
Citation Abdalwahab A, Al-atta A, Zaman A, Alkhalil M. Intensive lipid-lowering therapy, time to think beyond low-density lipoprotein cholesterol. World J Cardiol 2021; In press
Received
2021-03-22 21:44
Peer-Review Started
2021-03-21 15:32
To Make the First Decision
Return for Revision
2021-05-13 02:59
Revised
2021-05-25 05:48
Second Decision
2021-07-21 03:30
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-07-21 08:11
Articles in Press
2021-07-21 08:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1949-8462 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Ya-Juan Ma
Reviewer Code 00505984
Editorial Director
Journal Chief Editor
Company Chief Editor Jia-Ping Yan
Language Editor
Production Editor
Responsible Production Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 66147_Auto_Edited-JPY.docx
Answering Reviewers 66147-Answering reviewers.pdf
Audio Core Tip 66147-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 66147-Conflict-of-interest statement.pdf
Copyright License Agreement 66147-Copyright license agreement.pdf
Peer-review Report 66147-Peer-review(s).pdf
Scientific Misconduct Check 66147-Scientific misconduct check.pdf
Scientific Editor Work List 66147-Scientific editor work list.pdf