Publication Name	World Journal of Cardiology
Manuscript ID	66341
Country	Greece

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Review
Article Title	Exercise-mediated adaptations in vascular function and structure: Beneficial effects in coronary artery disease
Manuscript Source	Invited Manuscript
All Author List	Xenofon M Sakellariou, Michail I Papafaklis, Eleni M Domouzoglou, Christos S Katsouras, Lampros K Michalis and Katerina K Naka
Funding Agency and Grant Number
Corresponding Author	Michail I Papafaklis, FESC, MD, PhD, Attending Doctor, Consultant Physician-Scientist, Michailideion Cardiac Centre, University of Ioannina, Stavrou Niarchou Avenue, Ioannina 45100, Epirus, Greece. m.papafaklis@yahoo.com
Key Words	Exercise; Endothelium; Flow-mediated dilation; Endothelial shear stress; Coronary artery disease; Hemodynamics
Core Tip	Exercise has beneficial effects on the function and structure of the vasculature, thereby leading to a reduction of the cardiovascular risk. Hemodynamic forces, in particular endothelial shear stress, play a critical role in modulating the endothelial cell phenotype towards atherogenesis or atheroprotection. Exercise improves clinical outcomes in patients with coronary artery disease (CAD). We herein discuss the alterations induced by exercise on vascular function and structure, and the mechanisms involved in the benefits of exercise regarding patients with CAD.
Citation	Sakellariou XM, Papafaklis MI, Domouzoglou EM, Katsouras CS, Michalis LK, Naka KK. Exercise-mediated adaptations in vascular function and structure: Beneficial effects in coronary artery disease. World J Cardiol 2021; 13(9): 399-415

Received	2021-03-25 19:42
Peer-Review Started	2021-03-25 19:46
To Make the First Decision
Return for Revision	2021-05-13 02:56
Revised	2021-05-30 15:34
Second Decision	2021-07-21 03:30
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-07-21 08:53
Articles in Press	2021-07-21 08:53
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-08-01 04:25
Typeset the Manuscript	2021-09-16 03:56

ISSN	1949-8462 (online)
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