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Publication Name World Journal of Biological Chemistry
Manuscript ID 66383
Country/Territory France
Category Endocrinology and Metabolism
Manuscript Type Basic Study
Article Title Increased monoamine oxidase activity and imidazoline binding sites in insulin-resistant adipocytes from obese Zucker rats
Manuscript Source Invited Manuscript
All Author List Christian Carpéné, Luc Marti and Nathalie Morin
Funding Agency and Grant Number
Funding Agency Grant Number
Recurrent Grants from Institut National de la Santé et de la Recherche Médicale to the INSERM U1048
Corresponding Author Christian Carpéné, PhD, Senior Researcher, Institut des Maladies Métaboliques et Cardiovasculaires, INSERM, CHU Rangueil, Bat. L4, BP 84225 , Toulouse 31342, France. christian.carpene@inserm.fr
Key Words Obesity; Adipocyte; Amine oxidases; Imidazoline binding sites; Creatine kinase B; Idazoxan; Lipogenesis; Hydrogen peroxide; Glucose uptake
Core Tip The substrates of monoamine oxidase (MAO) and semicarbazide-sensitive amine oxidase (SSAO) partly reproduce the stimulatory effect of insulin on sugar entry in rat fat cells. Especially when combined with vanadium, tyramine and benzylamine mimic more than 70% of the insulin stimulation of glucose uptake. Unfortunately, such insulin activation of glucose utilization is strongly diminished in the genetically obese Zucker rat, an animal model of the metabolic syndrome. In this insulin-resistant and obese rat, the stimulation of glucose transport by tyramine is decreased as much as that of insulin, while the effect of benzylamine is even more altered. SSAO, responsible for benzylamine oxidation, is down-regulated in adipocytes from obese Zucker rats. In contrast, MAO, which predominantly supports the oxidation of tyramine, is increased, apparently not in a sufficient manner to reach the same hexose uptake activation seen in fat cells from lean rats. However, this greater ability to oxidize tyramine was found only in white adipocytes from obese rats since no change was found in the liver or skeletal muscle when compared to lean controls. Moreover, increased MAO activity in the large adipocytes of obese rats was accompanied by an enlarged number of imidazoline binding sites, previously described to be located on MAO. Since the repeated subcutaneous administration of tyramine plus vanadate is somewhat capable of reducing plasma glucose and triglycerides in obese rats, SSAO, MAO, and its associated imidazoline I2 sites deserve further studies with respect to their mimicking insulin action on glucose and lipid metabolism in fat cells.
Citation Carpéné C, Marti L, Morin N. Increased monoamine oxidase activity and imidazoline binding sites in insulin-resistant adipocytes from obese Zucker rats. World J Biol Chem 2022; 13(1): 15-34
Received
2021-03-26 15:36
Peer-Review Started
2021-03-26 15:40
To Make the First Decision
Return for Revision
2021-07-08 07:17
Revised
2021-07-09 10:38
Second Decision
2022-01-13 05:35
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-01-14 06:34
Articles in Press
2022-01-14 06:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
2021-12-01 02:24
Typeset the Manuscript
2022-01-19 17:20
ISSN 1949-8454 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Han Zhang (Online Science Editor)
Reviewer Code 05821062
Editorial Director
Journal Chief Editor
Company Chief Editor Lian-Sheng Ma
Language Editor Tian-Qi Wang
Production Editor Ying-Yi Yuan
Responsible Production Editor Ying-Yi Yuan
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Full Article (PDF) WJBC-13-15.pdf
Full Article (Word) WJBC-13-15.docx
Manuscript File 66383_Auto_Edited.docx
Answering Reviewers 66383-Answering reviewers.pdf
Audio Core Tip 66383-Audio core tip.mp4
Biostatistics Review Certificate 66383-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 66383-Conflict-of-interest statement.pdf
Copyright License Agreement 66383-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 66383-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 66383-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 66383-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 66383-Language certificate.pdf
Peer-review Report 66383-Peer-review(s).pdf
Scientific Misconduct Check 66383-Bing-Liu M-1.png
Scientific Editor Work List 66383-Scientific editor work list.pdf