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Publication Name World Journal of Cardiology
Manuscript ID 66521
Country/Territory Greece
Category Cardiac and Cardiovascular Systems
Manuscript Type Meta-Analysis
Article Title Cardiovascular efficacy and safety of dipeptidyl peptidase-4 inhibitors: A meta-analysis of cardiovascular outcome trials
Manuscript Source Invited Manuscript
All Author List Dimitrios Ioannis Patoulias, Aristi Boulmpou, Eleftherios Teperikidis, Alexandra Katsimardou, Fotios Siskos, Michael Doumas, Christodoulos E Papadopoulos and Vassilios Vassilikos
Funding Agency and Grant Number
Corresponding Author Dimitrios Ioannis Patoulias, MD, MSc, Doctor, Research Fellow, Research Scientist, Second Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, Hippokration General Hospital, Konstantinoupoleos 49 Str., Thessaloniki 54642, Greece. dipatoulias@gmail.com
Key Words Dipeptidyl peptidase-4 inhibitors; Cardiovascular outcomes; Atrial fibrillation; Atrial flutter; Type 2 diabetes mellitus
Core Tip The antidiabetic efficacy of dipeptidyl peptidase-4 (DPP-4) inhibitors has already been proven in recently published large randomized controlled trials. The purpose of the present meta-analysis was to clarify the impact of antidiabetic therapy with DPP-4 inhibitors on surrogate cardiovascular outcomes, and to elucidate the effect of these drugs on major cardiac arrhythmias. According to our analysis, this drug class does not significantly affect the risk for any of the addressed cardiovascular outcomes; however, it increases the risk for atrial flutter compared to placebo.
Citation Patoulias DI, Boulmpou A, Teperikidis E, Katsimardou A, Siskos F, Doumas M, Papadopoulos CE, Vassilikos V. Cardiovascular efficacy and safety of dipeptidyl peptidase-4 inhibitors: A meta-analysis of cardiovascular outcome trials. World J Cardiol 2021; In press
Received
2021-03-29 18:39
Peer-Review Started
2021-03-29 18:42
To Make the First Decision
Return for Revision
2021-06-25 10:53
Revised
2021-07-08 09:10
Second Decision
2021-09-09 03:22
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-09-10 09:27
Articles in Press
2021-09-10 09:27
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1949-8462 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Ya-Juan Ma
Reviewer Code 05449455, 05845795, and 05845795
Editorial Director
Journal Chief Editor
Company Chief Editor Lian-Sheng Ma
Language Editor
Production Editor
Responsible Production Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 66521_Auto_Edited.docx
Answering Reviewers 66521-Answering reviewers.pdf
Audio Core Tip 66521-Audio core tip.mp3
Biostatistics Review Certificate 66521-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 66521-Conflict-of-interest statement.pdf
Copyright License Agreement 66521-Copyright license agreement.pdf
Supplementary Material 66521-Supplementary material.pdf
Peer-review Report 66521-Peer-review(s).pdf
Scientific Editor Work List 66521-Scientific editor work list.pdf