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Publication Name World Journal of Cardiology
Manuscript ID 66521
Country/Territory Greece
Category Cardiac & Cardiovascular Systems
Manuscript Type Meta-Analysis
Article Title Cardiovascular efficacy and safety of dipeptidyl peptidase-4 inhibitors: A meta-analysis of cardiovascular outcome trials
Manuscript Source Invited Manuscript
All Author List Dimitrios Ioannis Patoulias, Aristi Boulmpou, Eleftherios Teperikidis, Alexandra Katsimardou, Fotios Siskos, Michael Doumas, Christodoulos E Papadopoulos and Vassilios Vassilikos
Funding Agency and Grant Number
Corresponding Author Dimitrios Ioannis Patoulias, MD, MSc, Doctor, Research Fellow, Research Scientist, Second Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, Hippokration General Hospital, Konstantinoupoleos 49 Str., Thessaloniki 54642, Greece. dipatoulias@gmail.com
Key Words Dipeptidyl peptidase-4 inhibitors; Cardiovascular outcomes; Atrial fibrillation; Atrial flutter; Type 2 diabetes mellitus
Core Tip The antidiabetic efficacy of dipeptidyl peptidase-4 (DPP-4) inhibitors has already been proven in recently published large randomized controlled trials. The purpose of the present meta-analysis was to clarify the impact of antidiabetic therapy with DPP-4 inhibitors on surrogate cardiovascular outcomes, and to elucidate the effect of these drugs on major cardiac arrhythmias. According to our analysis, this drug class does not significantly affect the risk for any of the addressed cardiovascular outcomes; however, it increases the risk for atrial flutter compared to placebo.
Citation Patoulias DI, Boulmpou A, Teperikidis E, Katsimardou A, Siskos F, Doumas M, Papadopoulos CE, Vassilikos V. Cardiovascular efficacy and safety of dipeptidyl peptidase-4 inhibitors: A meta-analysis of cardiovascular outcome trials. World J Cardiol 2021; 13(10): 585-592
Received
2021-03-29 18:39
Peer-Review Started
2021-03-29 18:42
To Make the First Decision
Return for Revision
2021-06-25 10:53
Revised
2021-07-08 09:10
Second Decision
2021-09-09 03:22
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-09-10 09:27
Articles in Press
2021-09-10 09:27
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2021-10-20 05:05
ISSN 1949-8462 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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