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5/8/2022 7:21:39 AM | Browse: 39 | Download: 38
Publication Name World Journal of Critical Care Medicine
Manuscript ID 66710
Country/Territory United States
Category Critical Care Medicine
Manuscript Type Minireviews
Article Title Challenges in hyperglycemia management in critically ill patients with COVID-19
Manuscript Source Invited Manuscript
All Author List Rajesh Kethireddy, Darshan Gandhi, Asim Kichloo and Love Patel
Funding Agency and Grant Number
Corresponding Author Darshan Gandhi, MD, Academic Fellow, Doctor, Department of Diagnostic Radiology, University of Tennessee Health Science Center, 920 Madison Ave, TN, Memphis 38103, United States. darshan.gandhi@northwestern.edu
Key Words Hyperglycemia; COVID-19; Critical care; Diabetes; Diabetic ketoacidosis
Core Tip Hyperglycemia is commonly associated with adverse outcomes especially in patients requiring intensive care unit stay. Data from the corona virus disease 2019 (COVID-19) pandemic indicates that individuals with diabetes appear to be at similar risk for COVID-19 infection to those without diabetes but are more likely to experience increased morbidity and mortality. The proposed hypothesis for hyperglycemia in COVID-19 include insulin resistance, critical illness hyperglycemia (or stress- induced hyperglycemia) secondary to high levels of hormones like cortisol and catecholamines that counteract insulin action, acute cytokine storm and pancreatic cell dysfunction. Diabetic patients are more likely to have severe hyperglycemic complications including diabetic ketoacidosis and hyperosmolar hyperglycemic state. Management of hyperglycemia in COVID-19 is often complicated by use of steroids, prolonged total parenteral or enteral nutrition, frequent acute hyperglycemic events, and restrictions with fluid management due to acute respiratory distress syndrome. While managing hyperglycemia special attention should be paid to mode of insulin delivery, frequency of glucose monitoring based on patient and caregiver safety thereby minimizing exposure and conserving personal protective equipment. In this article we describe the pathophysiology of hyperglycemia, challenges encountered in managing hyperglycemia, and review some potential solutions to address them.
Citation Kethireddy R, Gandhi D, Kichloo A, Patel L. Challenges in hyperglycemia management in critically ill patients with COVID-19. World J Crit Care Med 2022; In press
Received
2021-04-02 21:58
Peer-Review Started
2021-04-02 22:01
To Make the First Decision
Return for Revision
2021-07-31 04:00
Revised
2021-08-10 03:27
Second Decision
2022-05-07 07:56
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-05-08 07:21
Articles in Press
2022-05-08 07:21
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 2220-3141(online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Yun-Xiaojian Wu
Reviewer Code 05430684, and 05935566
Editorial Director
Journal Chief Editor
Company Chief Editor Lian-Sheng Ma
Language Editor
Production Editor
Responsible Production Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 66710_Auto_Edited.docx
Answering Reviewers 66710-Answering reviewers.pdf
Audio Core Tip 66710-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 66710-Conflict-of-interest statement.pdf
Copyright License Agreement 66710-Copyright license agreement.pdf
Peer-review Report 66710-Peer-review(s).pdf
Scientific Misconduct Check 66710-Bing-Wu YXJ-2.png
Scientific Editor Work List 66710-Scientific editor work list.pdf