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Publication Name World Journal of Clinical Oncology
Manuscript ID 66772
Country/Territory United States
Category Gastroenterology and Hepatology
Manuscript Type Retrospective Cohort Study
Article Title Uptake and outcomes of small intestinal and urinary tract cancer surveillance in Lynch syndrome
Manuscript Source Invited Manuscript
All Author List Jeshua DeJesse, Ravy K Vajravelu, Christina Dudzik, Gillain Constantino, Jessica M Long, Kirk J Wangensteen, Kathleen D Valverde and Bryson W Katona
Funding Agency and Grant Number
Funding Agency Grant Number
NIH 5R03DK120946-02
Corresponding Author Bryson W Katona, MD, PhD, Assistant Professor, Division of Gastroenterology and Hepatology, University of Pennsylvania Perelman School of Medicine, 3400 Civic Center Blvd, 751 South Pavilion, Philadelphia, Pennsylvania 19104, United States. bryson.katona@pennmedicine.upenn.edu
Key Words Lynch syndrome; Urinary tract cancer; Intestinal neoplasms; Early diagnosis of cancer; Patient preference; Gastrointestinal surgical procedure
Core Tip This retrospective study of a Lynch syndrome (LS) cohort measured the uptake and outcome of small intestinal cancer (SIC) and urinary tract cancer (UTC) surveillance. When given the option of surveillance, a minority of patients elected surveillance, and patient completion of surveillance exams was suboptimal. Completed surveillance exams rarely detected SIC/UTC and resulted in multiple false positives that led to additional follow-up procedures. Pursuing and completing SIC/UTC surveillance in LS was influenced by several factors, however given the low yield and positive predictive value, broad incorporation of SIC/UTC surveillance in LS management is unlikely to be helpful.
Citation DeJesse J, Vajravelu RK, Dudzik C, Constantino G, Long JM, Wangensteen KJ, Valverde KD, Katona BW. Uptake and outcomes of small intestinal and urinary tract cancer surveillance in Lynch syndrome. World J Clin Oncol 2021; 12(11): 1023-1036
Received
2021-04-13 14:27
Peer-Review Started
2021-04-13 14:28
To Make the First Decision
Return for Revision
2021-07-07 17:59
Revised
2021-07-26 13:27
Second Decision
2021-10-11 08:28
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-10-14 03:04
Articles in Press
2021-10-14 03:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2021-11-17 06:04
ISSN 2218-4333 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Li-Li Wang
Reviewer Code 04737354
Editorial Director
Journal Chief Editor
Company Chief Editor Lian-Sheng Ma
Language Editor
Production Editor Ying-Yi Yuan
Responsible Production Editor Ying-Yi Yuan
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Full Article (PDF) WJCO-12-1023.pdf
Full Article (Word) WJCO-12-1023.docx
Manuscript File 66772_Auto_Edited.docx
Answering Reviewers 66772-Answering reviewers.pdf
Audio Core Tip 66772-Audio core tip.mp3
Biostatistics Review Certificate 66772-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 66772-Conflict-of-interest statement.pdf
Copyright License Agreement 66772-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 66772-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 66772-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 66772-Institutional review board statement.pdf
Supplementary Material 66772-Supplementary material.pdf
Peer-review Report 66772-Peer-review(s).pdf
Scientific Misconduct Check 66772-Bing-Wang LL-2.png
Scientific Editor Work List 66772-Scientific editor work list.pdf