Publication Name	World Journal of Gastrointestinal Endoscopy
Manuscript ID	67140
Country	Italy

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Efficacy and tolerability of high and low-volume bowel preparation compared: A real-life single-blinded large-population study
Manuscript Source	Invited Manuscript
All Author List	Vincenzo Occhipinti, Paola Soriani, Francesco Bagolini, Valentina Milani, Emanuele Rondonotti, Maria Laura Annunziata, Flaminia Cavallaro, Sara Vavassori, Maurizio Vecchi, Luca Pastorelli and Gian Eugenio Tontini
Funding Agency and Grant Number
Corresponding Author	Luca Pastorelli, MD, PhD, Associate Professor, Gastroenterology Unit, IRCCS Policlinico San Donato, Piazza Malan, San Donato Milanese 20097, Italy. luca.pastorelli@unimi.it
Key Words	Bowel preparation volume; Polyethylene glycol; Bisacodyl; Colonoscopy; Colonic adenomas; Tolerability
Core Tip	Quality of bowel preparation is one of the main factors influencing outcomes of colonoscopy. This prospective real-life study compared bowel cleansing (according to the Boston Bowel Preparation Scale), clinically relevant colonoscopy outcomes (lesions detection rate) and tolerability of a standard high-volume bowel preparation and a low-volume preparation (2 L polyethylene glycol + bisacodyl). Even if the two study groups did not show differences in terms of adequate bowel preparation, the use of the high-volume preparation was associated with higher polyp and adenoma detection rates. There were no differences in terms of advanced adenomas, sessile/serrated lesions and cancer detections. Performance of low-volume preparation seems influenced by image resolution of colonoscopes, with fewer lesions detected compared to high-volume when using standard-definition colonoscopes. The two preparations were comparable in terms of patients’ self-reported tolerability, but complete adherence to preparation was more common with the low-volume product.
Citation	Occhipinti V, Soriani P, Bagolini F, Milani V, Rondonotti E, Annunziata ML, Cavallaro F, Vavassori S, Vecchi M, Pastorelli L, Tontini GE. Efficacy and tolerability of high and low-volume bowel preparation compared: A real-life single-blinded large-population study. World J Gastrointest Endosc 2021; 13(12): 659-672

Received	2021-04-24 11:11
Peer-Review Started	2021-04-24 11:15
To Make the First Decision
Return for Revision	2021-06-14 07:24
Revised	2021-06-25 13:22
Second Decision	2021-12-02 03:26
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-12-03 06:56
Articles in Press	2021-12-03 06:56
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-12-08 10:45

ISSN	1948-5190 (online)
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