Publication Name	World Journal of Psychiatry
Manuscript ID	67654
Country	United States

Category	Neurosciences
Manuscript Type	Review
Article Title	Brain-derived neurotrophic factor and inflammation in depression: Pathogenic partners in crime?
Manuscript Source	Invited Manuscript
All Author List	Grace A Porter and Jason C O’Connor
Funding Agency and Grant Number	Funding Agency Grant Number National Institutes of Health TL1 TR002647 Veterans Affairs I01BX003195
Corresponding Author	Jason C O’Connor, PhD, Associate Professor, Department of Pharmacology, University of Texas Health San Antonio, 216B Medical Building MC-7764, 7703 Floyd Curl Drive, San Antonio, TX 78229, United States. oconnorj@uthscsa.edu
Key Words	Brain-derived neurotrophic factor; Microglia; Neuroinflammation; Growth factors; Depression
Core Tip	Low levels of brain-derived neurotrophic factor (BDNF) and high inflammation have both been implicated as risk factors in the pathogenesis of major depressive disorder. Here we review the role BDNF and inflammation play in the etiology of depression and the interaction between them. Recent evidence suggests a bidirectional connection between these two risk factors: inflammation reduces BDNF expression, and BDNF may have a negative regulatory role in resolving neuroinflammation. Understanding of this interaction in the context of neuropsychiatric disease is important for a fuller understanding of biological pathogenesis of depression and for identifying novel therapeutic opportunities.
Citation	Porter GA, O’Connor JC. Brain-derived neurotrophic factor and inflammation in depression: Pathogenic partners in crime? World J Psychiatr 2022; 12(1): 77-97

Received	2021-04-28 15:50
Peer-Review Started	2021-04-28 15:53
To Make the First Decision
Return for Revision	2021-07-14 22:11
Revised	2021-07-21 18:31
Second Decision	2021-12-01 03:22
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-12-02 01:54
Articles in Press	2021-12-02 01:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-12-31 02:42

ISSN	2220-3206 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com